UBE2C and PSMD4

Number of citations of the paper that reports this interaction (PubMedID 20007692)
43

Data Source:
BioGRID (pull down)

		UBE2C	PSMD4
Description		ubiquitin conjugating enzyme E2 C	proteasome 26S subunit ubiquitin receptor, non-ATPase 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	RNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		Height ( 31562340)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		36 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 HECTD3 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RBX1 RELA RNF167 RNF31 RNF6 RNF7 RYR2 STUB1 TNNC1 TRIM13 TRIM2 TRIM21 TRIM28 TRIM29 UBA1 UBA6 UBASH3B UBC UBE3D	46 interacting genes: ADRM1 APP BTRC CCNA2 CFTR CUL1 EGFR FBXO25 FLOT1 GNB5 H2AC4 H2BC3 ID1 MAP3K1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 OGT PRKN PTEN RAD23A RAD23B RASSF8 RBCK1 RBM11 SCHIP1 SIAH2 SMURF1 SREBF2 STUB1 TCF3 TCP11L1 TMEM129 TP53 TRIM63 UBB UBC UBD UBE2C UBQLN1 UBQLN2 WWP2 XPC
Entrez ID		11065	5710
HPRD ID		05717	03386
Ensembl ID		ENSG00000175063	ENSG00000159352
Uniprot IDs		A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3	P55036 Q5VWC4
PDB IDs		1I7K 4YII 5A31 5KHR 5L9U 8TAR 8TAU	1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6MUN 6U19 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Catabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-ubiquitin Ligase Activity Cullin Family Protein Binding Protein K6-linked Ubiquitination Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein K29-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Zinc Ion Binding Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K27-linked Ubiquitination Suppression Of Viral Release By Host SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Anaphase-promoting Complex Ubiquitin Activating Enzyme Activity Ubiquitin-like Protein Ligase Activity Anaphase-promoting Complex-dependent Catabolic Process	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Macromolecule Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis Protein Catabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Proteasome Binding Cytoplasm Cellular Response To Stress Protein-folding Chaperone Binding Ubiquitin Binding Regulation Of Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Ubiquitin Ligase Complex Regulation Of Signal Transduction Protein Destabilization
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