UBE2C and UBE3D

Number of citations of the paper that reports this interaction (PubMedID 15749827)
0

Data Source:
BioGRID (pull down)

		UBE2C	UBE3D
Description		ubiquitin conjugating enzyme E2 C	ubiquitin protein ligase E3D
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Ribonuclease Inhibitor Activity Transferase Activity Cyclin Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Protein Polyubiquitination Protein Monoubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 31562340)	Adult body size ( 32376654) Crohn's disease ( 26891255) Entorhinal cortical volume ( 31530798) Heel bone mineral density ( 28869591 30598549) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189)
Interacting Genes		36 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 HECTD3 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RBX1 RELA RNF167 RNF31 RNF6 RNF7 RYR2 STUB1 TNNC1 TRIM13 TRIM2 TRIM21 TRIM28 TRIM29 UBA1 UBA6 UBASH3B UBC UBE3D	5 interacting genes: CCNB1 MAGEA11 PCNA TRIM28 UBE2C
Entrez ID		11065	90025
HPRD ID		05717	12861
Ensembl ID		ENSG00000175063	ENSG00000118420
Uniprot IDs		A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3	D6RD24 Q4G0J6 Q4G0X5 Q7Z6J8
PDB IDs		1I7K 4YII 5A31 5KHR 5L9U 8TAR 8TAU
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Catabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-ubiquitin Ligase Activity Cullin Family Protein Binding Protein K6-linked Ubiquitination Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein K29-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Zinc Ion Binding Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K27-linked Ubiquitination Suppression Of Viral Release By Host SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Anaphase-promoting Complex Ubiquitin Activating Enzyme Activity Ubiquitin-like Protein Ligase Activity Anaphase-promoting Complex-dependent Catabolic Process	Ubiquitin-like Protein Ligase Binding Cellular Response To Iron(III) Ion Positive Regulation Of Mitotic Cell Cycle Phase Transition Response To DDT Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Sister Chromatid Separation Regeneration Regulation Of Chromosome Separation PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Nucleoplasm Positive Regulation Of DNA Repair Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Ubiquitin-like Protein Ligase Activity Response To Iron(III) Ion Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Embryonic Placenta Morphogenesis Positive Regulation Of Exit From Mitosis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA 3'-end Processing Response To Insecticide Regulation Of Primary Metabolic Process Regulation Of Chromosome Organization Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Repair MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization
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