IL7 and IL7R

Number of citations of the paper that reports this interaction (PMID 10390077)
14

Data Source:
HPRD (in vivo, in vitro)

		IL7	IL7R
Gene Name		interleukin 7	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	T Cell Lineage Commitment Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Bone Resorption Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system	Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		4 interactors: APP CEBPE IL2RG IL7R	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		3574	3575
HPRD ID		00892	00893
Ensembl ID		ENSG00000104432	ENSG00000168685
Uniprot IDs		A8K673 P13232 Q5FBX5	D6RGV2 D9N160 P16871
PDB IDs		1IL7 3DI2 3DI3	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Interleukin-7-mediated Signaling Pathway Immune System Process Cell Growth Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Interleukin-2-mediated Signaling Pathway Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Leukocyte Differentiation Neuron Remodeling Response To Interleukin-2 Cellular Response To Organic Substance Interleukin-4-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Growth Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Cellular Copper Ion Homeostasis Macrophage Differentiation Cellular Response To Cytokine Stimulus Copper Ion Homeostasis Suckling Behavior Hemopoiesis Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Endocytosis Response To Organic Substance Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Immune System Development Response To Cytokine Cytokine Metabolic Process Regulation Of T Cell Differentiation In Thymus Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Adaptive Immune Response Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway B Cell Proliferation Cellular Response To Interleukin-4	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?