IL7

Name	interleukin 7
Structure
Novel Interactors	1 novel interactors: LYN
Interactors	5 interactors: APP CEBPE FBXO7 IL2RG IL7R
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Cytokine-mediated Signaling Pathway T Cell Lineage Commitment Immune Response Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Organ Growth Interleukin-7-mediated Signaling Pathway B Cell Proliferation Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways	Interleukin-7 signaling Interleukin-7 signaling
GWAS	Blood protein levels ( 30072576 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 21833088 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Suicide in bipolar disorder ( 25917933 )
Entrez ID	3574
HPRD ID	00892
Ensembl ID	ENSG00000104432
Uniprot IDs	A0A0A0MTG5 A8K673 P13232 Q5FBX5
PDB IDs	3DI2 3DI3
GO Terms Enriched among Interactors ?	Mononuclear Cell Differentiation Leukocyte Differentiation Interleukin-7 Receptor Activity Leukocyte Activation Regulation Of Cell Activation Cell Activation Signaling Receptor Activator Activity Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Lymphocyte Activation Hemopoiesis Cellular Developmental Process Regulation Of T Cell Differentiation In Thymus B Cell Activation Regulation Of Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Ephrin Receptor Binding Granulocyte Differentiation Regulation Of Lymphocyte Differentiation B Cell Homeostasis Regulation Of Monocyte Chemotaxis Lymphocyte Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Cell Development Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion B Cell Proliferation Positive Regulation Of Cell Differentiation T Cell Differentiation In Thymus Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Positive Regulation Of Immune System Process Regulation Of Lymphocyte Apoptotic Process Lymphocyte Homeostasis Glial Cell Development Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of T Cell Activation Cell Differentiation Cytokine-mediated Signaling Pathway Amyloid-beta Complex Immune Response