IL7

Gene Name		interleukin 7
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	T Cell Lineage Commitment Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Bone Resorption Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-protein Interactions		4 interactors: APP CEBPE IL2RG IL7R
Entrez ID		3574
HPRD ID		00892
Ensembl ID		ENSG00000104432
Uniprot IDs		A8K673 P13232 Q5FBX5
PDB IDs		1IL7 3DI2 3DI3
Enriched GO Terms of Interacting Partners?		Interleukin-7-mediated Signaling Pathway Immune System Process Cell Growth Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Interleukin-2-mediated Signaling Pathway Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Leukocyte Differentiation Neuron Remodeling Response To Interleukin-2 Cellular Response To Organic Substance Interleukin-4-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Growth Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Cellular Copper Ion Homeostasis Macrophage Differentiation Cellular Response To Cytokine Stimulus Copper Ion Homeostasis Suckling Behavior Hemopoiesis Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Endocytosis Response To Organic Substance Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Immune System Development Response To Cytokine Cytokine Metabolic Process Regulation Of T Cell Differentiation In Thymus Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Adaptive Immune Response Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway B Cell Proliferation Cellular Response To Interleukin-4
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous