IL7 and IL2RG

Number of citations of the paper that reports this interaction (PMID 11858939)
12

Data Source:
HPRD (in vitro, in vivo)

		IL7	IL2RG
Gene Name		interleukin 7	interleukin 2 receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding
	Biological Process	T Cell Lineage Commitment Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Bone Resorption Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		4 interactors: APP CEBPE IL2RG IL7R	24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3574	3561
HPRD ID		00892	02391
Ensembl ID		ENSG00000104432	ENSG00000147168
Uniprot IDs		A8K673 P13232 Q5FBX5	P31785 Q5FC09
PDB IDs		1IL7 3DI2 3DI3	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7
Enriched GO Terms of Interacting Partners?		Interleukin-7-mediated Signaling Pathway Immune System Process Cell Growth Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Interleukin-2-mediated Signaling Pathway Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Leukocyte Differentiation Neuron Remodeling Response To Interleukin-2 Cellular Response To Organic Substance Interleukin-4-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Growth Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Cellular Copper Ion Homeostasis Macrophage Differentiation Cellular Response To Cytokine Stimulus Copper Ion Homeostasis Suckling Behavior Hemopoiesis Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Endocytosis Response To Organic Substance Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Immune System Development Response To Cytokine Cytokine Metabolic Process Regulation Of T Cell Differentiation In Thymus Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Adaptive Immune Response Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway B Cell Proliferation Cellular Response To Interleukin-4	Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?