IL7 and CEBPE

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL7	CEBPE
Gene Name		interleukin 7	CCAAT/enhancer binding protein (C/EBP), epsilon
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	T Cell Lineage Commitment Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Bone Resorption Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transcription, DNA-templated Phagocytosis Defense Response Macrophage Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Acute lymphoblastic leukemia (childhood) ( 23512250 19684604)
Protein-Protein Interactions		4 interactors: APP CEBPE IL2RG IL7R	44 interactors: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TCEB2 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		3574	1053
HPRD ID		00892	02852
Ensembl ID		ENSG00000104432	ENSG00000092067
Uniprot IDs		A8K673 P13232 Q5FBX5	Q15744
PDB IDs		1IL7 3DI2 3DI3	3T92
Enriched GO Terms of Interacting Partners?		Interleukin-7-mediated Signaling Pathway Immune System Process Cell Growth Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Interleukin-2-mediated Signaling Pathway Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Leukocyte Differentiation Neuron Remodeling Response To Interleukin-2 Cellular Response To Organic Substance Interleukin-4-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Growth Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Cellular Copper Ion Homeostasis Macrophage Differentiation Cellular Response To Cytokine Stimulus Copper Ion Homeostasis Suckling Behavior Hemopoiesis Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Endocytosis Response To Organic Substance Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Immune System Development Response To Cytokine Cytokine Metabolic Process Regulation Of T Cell Differentiation In Thymus Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Adaptive Immune Response Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway B Cell Proliferation Cellular Response To Interleukin-4	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cellular Process Myeloid Cell Differentiation Hemopoiesis Myeloid Leukocyte Differentiation Cellular Metabolic Process Immune System Development Negative Regulation Of Cellular Metabolic Process Organ Development Dendritic Cell Differentiation Anatomical Structure Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity System Development Myeloid Dendritic Cell Differentiation Leukocyte Activation Myeloid Dendritic Cell Activation
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il4 il4r il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Intersection) ?