IL4R and ERN2

		IL4R	ERN2
Description		interleukin 4 receptor	endoplasmic reticulum to nucleus signaling 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Quality Control Compartment IRE1-TRAF2-ASK1 Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Metal Ion Binding Unfolded Protein Binding Protein Serine Kinase Activity
	Biological Process	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion	Regulation Of DNA-templated Transcription MRNA Processing RNA Catabolic Process Protein Phosphorylation Apoptotic Process RRNA Catabolic Process Apoptotic Chromosome Condensation Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	1 interacting genes: RNF10
Entrez ID		3566	10595
HPRD ID		00990	04944
Ensembl ID		ENSG00000077238	ENSG00000134398
Uniprot IDs		B2RBY1 P24394	A5YM46 A5YM65 E7ETG2 Q76MJ5
PDB IDs		1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation T Cell Differentiation Involved In Immune Response Negative Regulation Of Developmental Process Negative Regulation Of T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Macrophage Activation Regulation Of Type 2 Immune Response T-helper Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Regulation Of Myoblast Fusion B Cell Mediated Immunity Positive Regulation Of Type 2 Immune Response Response To Protozoan Regulation Of Cell Development T-helper 1 Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Cell Development Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Mast Cell Degranulation Cytokine Receptor Activity Defense Response To Protozoan Production Of Molecular Mediator Involved In Inflammatory Response Interleukin-4 Receptor Activity Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Myoblast Fusion Regulation Of Mast Cell Degranulation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Postsynaptic Signal Transduction Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Myelination Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Regulation Of Myelination Extrinsic Component Of Postsynaptic Density Membrane Regulation Of T-helper Cell Differentiation
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