IL4R and SLC20A1

		IL4R	SLC20A1
Description		interleukin 4 receptor	solute carrier family 20 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex	Plasma Membrane Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding	Phosphate Transmembrane Transporter Activity High-affinity Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Symporter Activity Signaling Receptor Activity
	Biological Process	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion	Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Cell Population Proliferation Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling	Sodium-coupled phosphate cotransporters
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	4 interacting genes: BCL10 CRYAA MAPK6 RAPGEF1
Entrez ID		3566	6574
HPRD ID		00990	08846
Ensembl ID		ENSG00000077238	ENSG00000144136
Uniprot IDs		B2RBY1 P24394	A7LNJ1 Q8WUM9
PDB IDs		1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process	Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of T-helper 1 Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Interleukin-4 Receptor Activity Septin Cytoskeleton Polkadots Positive Regulation Of Lymphotoxin A Production Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response CBM Complex Positive Regulation Of Mast Cell Cytokine Production Tubulin Complex Assembly Response To UV-A Lens Fiber Cell Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Effector Process Positive Regulation Of Cell-cell Adhesion T-helper 2 Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T-helper 1 Cell Differentiation Immune Effector Process Positive Regulation Of T-helper 2 Cell Differentiation Regulation Of T Cell Activation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion MAP Kinase Activity Negative Regulation Of B Cell Apoptotic Process Kinase Activator Activity Antifungal Innate Immune Response CARD Domain Binding B Cell Apoptotic Process Protein Kinase B Binding General Transcription Initiation Factor Binding
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