IL1B and LYN

Number of citations of the paper that reports this interaction (PubMedID 9230816)
26

Data Source:
BioGRID (pull down)

		IL1B	LYN
Description		interleukin 1 beta	LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Cytosol Secretory Granule Vesicle	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Crista Endocytic Vesicle Membrane Mitochondrial Membrane Protein-containing Complex Integrin Alpha2-beta1 Complex Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Enzyme Binding Signaling Receptor Activator Activity Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Transmembrane Transporter Binding Protein-containing Complex Binding Ephrin Receptor Binding Phosphoprotein Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction JNK Cascade Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Carbohydrate Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of D-glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Ectopic Germ Cell Programmed Cell Death Positive Regulation Of T Cell Proliferation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Migration Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Interleukin-17 Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Regulation Of Secretion By Cell Negative Regulation Of Gap Junction Assembly Positive Regulation Of Tight Junction Disassembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	DNA Damage Checkpoint Signaling Cell Morphogenesis B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of B Cell Apoptotic Process Protein Phosphorylation Autophagy Response To Stress Inflammatory Response DNA Damage Response Response To Sterol Depletion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Fatty Acid Transport Peptidyl-tyrosine Phosphorylation Hemopoiesis Erythrocyte Differentiation Eosinophil Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-5-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis C-X-C Chemokine Receptor CXCR4 Signaling Pathway B Cell Proliferation Positive Regulation Of Phosphorylation Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Lipid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Neuroinflammatory Response Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Interleukin-1 processing Pyroptosis CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod	Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)	Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 27863252 32888494)
Interacting Genes		17 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FBXL2 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 NEDD4 PRTN3 SP1	124 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PRRG4 PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SOCS1 SPHK1 SPHK2 STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		3553	4067
HPRD ID		00985	01301
Ensembl ID		ENSG00000125538	ENSG00000254087
Uniprot IDs		P01584	A8K379 B4DQ79 P07948 Q6NUK7
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7CHY 7CHZ 7I1B 7Z4T 8C3U 8RYK 8RYS 8RZB 9ILB	1W1F 1WA7 3A4O 5XY1 6NMW 8WFF
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Inflammatory Response Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Cytokine Precursor Processing Interleukin-1-mediated Signaling Pathway Interleukin-1 Receptor Activity Immune System Process Interleukin-1 Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Proteolysis Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Cellular Response To Amyloid-beta Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Response To Stress Protein Processing Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Multicellular Organismal Process Endopeptidase Activity Membrane Raft Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ephrin Receptor Binding Protein Metabolic Process Peptidase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-1 Production Positive Regulation Of Intracellular Signal Transduction Collagen Catabolic Process Growth Factor Receptor Binding Signaling Receptor Ligand Precursor Processing Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Protein Maturation NLRP1 Inflammasome Complex Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Glutamate Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Metal Ion Transport Heparan Sulfate Binding	Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Plasma Membrane Antigen Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Apoptotic Process Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling B Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Adaptive Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Activation Immune Response T Cell Receptor Signaling Pathway Protein Kinase Activity Negative Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Protein Phosphorylation Regulation Of Multicellular Organismal Process B Cell Activation Regulation Of Transport Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Cell Activation Regulation Of MAPK Cascade External Side Of Plasma Membrane Leukocyte Activation Regulation Of Leukocyte Proliferation
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