IL1B and IL1R1

Number of citations of the paper that reports this interaction (PMID 9062193)
37

Data Source:
HPRD (in vitro)

		IL1B	IL1R1
Gene Name		interleukin 1, beta	interleukin 1 receptor, type I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Domain Specific Binding	Protease Binding Signal Transducer Activity Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Glucose Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Interleukin-1 Beta Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Monocyte Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs		Minocycline Gallium nitrate Canakinumab Rilonacept	Anakinra
Diseases
GWAS			Asthma ( 22561531) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	11 interactors: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		3553	3554
HPRD ID		00985	00994
Ensembl ID		ENSG00000125538	ENSG00000115594
Uniprot IDs		P01584	P14778
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB	1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Cellular Response To Organic Substance Immune System Process Response To Organic Substance Immune Response Cytokine Production Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Stimulus Response To Stimulus Blood Coagulation Hemostasis Platelet Activation Innate Immune Response Response To Stress Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Platelet Degranulation Regulation Of Protein Metabolic Process Interleukin-1-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Interleukin-1 Beta Production Cell Activation Response To Wounding Cell Differentiation Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Cytokine Biosynthetic Process Regulation Of Signal Transduction Defense Response Response To Organonitrogen Compound Cytokine-mediated Signaling Pathway Cytokine Metabolic Process Cellular Response To Organonitrogen Compound Cellular Response To Acid Chemical Organ Development Response To Carbohydrate Regulation Of Signaling Central Nervous System Development Axonogenesis Peptidyl-tyrosine Autophosphorylation Response To Mechanical Stimulus Dendritic Cell Differentiation	Inflammatory Response Defense Response Response To Cytokine Immune Response Fever Generation Heat Generation Acute-phase Response Cellular Response To Organic Substance Regulation Of Chemokine Production Cytokine-mediated Signaling Pathway Immune System Process Acute Inflammatory Response Response To Stress Regulation Of Cytokine Production Response To Organic Substance Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Cytokine Biosynthetic Process Signaling Response To Lipopolysaccharide Temperature Homeostasis Cell Communication Positive Regulation Of JNK Cascade Response To Molecule Of Bacterial Origin Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Cellular Response To Lipopolysaccharide Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Regulation Of JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Cellular Response To Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade Response To Bacterium Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process
Tagcloud ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering
Tagcloud (Difference) ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering
Tagcloud (Intersection) ?