IL1B and MMP2

Number of citations of the paper that reports this interaction (PubMedID 8663297)
0

Data Source:
HPRD (in vitro)

		IL1B	MMP2
Description		interleukin 1 beta	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Cytosol Secretory Granule Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding Receptor Ligand Activity	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction JNK Cascade Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Carbohydrate Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of D-glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Ectopic Germ Cell Programmed Cell Death Positive Regulation Of T Cell Proliferation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Migration Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Interleukin-17 Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Regulation Of Secretion By Cell Negative Regulation Of Gap Junction Assembly Positive Regulation Of Tight Junction Disassembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Interleukin-1 processing Pyroptosis CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FBXL2 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 NEDD4 PRTN3 SP1	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		3553	4313
HPRD ID		00985	00386
Ensembl ID		ENSG00000125538	ENSG00000087245
Uniprot IDs		P01584	P08253
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7CHY 7CHZ 7I1B 7Z4T 8C3U 8RYK 8RYS 8RZB 9ILB	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Inflammatory Response Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Cytokine Precursor Processing Interleukin-1-mediated Signaling Pathway Interleukin-1 Receptor Activity Immune System Process Interleukin-1 Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Proteolysis Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Cellular Response To Amyloid-beta Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Response To Stress Protein Processing Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Multicellular Organismal Process Endopeptidase Activity Membrane Raft Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ephrin Receptor Binding Protein Metabolic Process Peptidase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-1 Production Positive Regulation Of Intracellular Signal Transduction Collagen Catabolic Process Growth Factor Receptor Binding Signaling Receptor Ligand Precursor Processing Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Protein Maturation NLRP1 Inflammasome Complex Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Glutamate Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Metal Ion Transport Heparan Sulfate Binding	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis
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