IL1B and IL1RAP

Number of citations of the paper that reports this interaction (PMID 9820540)
13

Data Source:
HPRD (in vitro)

		IL1B	IL1RAP
Gene Name		interleukin 1, beta	interleukin 1 receptor accessory protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Domain Specific Binding	Signal Transducer Activity Interleukin-1 Receptor Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Glucose Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Interleukin-1 Beta Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Monocyte Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Complex Assembly Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response
Pathways		Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system
Drugs		Minocycline Gallium nitrate Canakinumab Rilonacept
Diseases
GWAS			Lung cancer ( 18385676) Waist circumference ( 20966902)
Protein-Protein Interactions		15 interactors: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	19 interactors: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCH8 MC4R MYD88 PIK3R1 PRKCI PRPF40A RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		3553	3556
HPRD ID		00985	04021
Ensembl ID		ENSG00000125538	ENSG00000196083
Uniprot IDs		P01584	A8K6K4 Q9NPH3
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB	3O4O 4DEP
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Cellular Response To Organic Substance Immune System Process Response To Organic Substance Immune Response Cytokine Production Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Stimulus Response To Stimulus Blood Coagulation Hemostasis Platelet Activation Innate Immune Response Response To Stress Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Platelet Degranulation Regulation Of Protein Metabolic Process Interleukin-1-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Interleukin-1 Beta Production Cell Activation Response To Wounding Cell Differentiation Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Cytokine Biosynthetic Process Regulation Of Signal Transduction Defense Response Response To Organonitrogen Compound Cytokine-mediated Signaling Pathway Cytokine Metabolic Process Cellular Response To Organonitrogen Compound Cellular Response To Acid Chemical Organ Development Response To Carbohydrate Regulation Of Signaling Central Nervous System Development Axonogenesis Peptidyl-tyrosine Autophosphorylation Response To Mechanical Stimulus Dendritic Cell Differentiation	Response To Cytokine Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Immune System Process Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cytokine Production Defense Response Response To Interleukin-1 Signaling Cell Communication Temperature Homeostasis Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Transcription Factor Activity Fever Generation Acute-phase Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Intracellular Signal Transduction Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Protein Transport Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Positive Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Regulation Of Chemokine Production Heat Generation Response To Stimulus
Tagcloud ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Difference) ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Intersection) ?