IGFBP2 and BMPR2

Data Source: HiPPIP (Novel)

		IGFBP2	BMPR2
Name		insulin like growth factor binding protein 2	bone morphogenetic protein receptor type 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body
	Molecular Function	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Signaling Receptor Inhibitor Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Osteoblast Differentiation Female Pregnancy Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Negative Regulation Of Osteoblast Differentiation Response To Steroid Hormone Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Signaling by BMP
Drugs		None	Dibotermin alfa Fostamatinib
GWAS		Glomerular filtration rate (creatinine) ( 28452372 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) Mitral valve prolapse ( 26301497 ) Thyroid stimulating hormone levels ( 25743335 ) Type 2 diabetes ( 26818947 )	High light scatter reticulocyte percentage of red cells ( 32888494 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular hemoglobin ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) PR interval ( 32439900 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32154731 32203549 ) Urate levels ( 23263486 )
Novel Interactors		3 novel interactors: BMPR2 CASP10 RPS6KA1	7 novel interactors: CASP10 CASP8 CHRND ERBB4 HAT1 IGFBP2 RAB11FIP1
Interacting Genes		6 interacting genes: GSDMB IGF1 IGF2 INO80B KLK2 TF	53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		3485	659
HPRD ID		00898	02880
Ensembl ID		ENSG00000115457	ENSG00000204217
Uniprot IDs		C9JMY1 P18065	Q13873
PDB IDs		2H7T	2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O
GO Terms Enriched among Interactors		Lung Vasculature Development Positive Regulation Of Growth Exocrine Pancreas Development Osteoblast Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Insulin Receptor Binding Epithelial Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cellular Component Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Glycogen Metabolic Process Blood Vessel Remodeling Regulation Of Activated T Cell Proliferation Lung Alveolus Development Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Vasculature Development Extracellular Space Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Developmental Growth Basal Plasma Membrane Platelet Alpha Granule Lumen Negative Regulation Of Oocyte Development Clathrin-coated Pit Negative Regulation Of Muscle Cell Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Insulin Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Tissue Remodeling Proteoglycan Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Organ Growth Cytotoxic T Cell Pyroptotic Cell Death Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Secretory Granule	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity