IGFBP2 and GSDMB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IGFBP2	GSDMB
Gene Name		insulin-like growth factor binding protein 2, 36kDa	gasdermin B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS			Asthma ( 21804549 20860503) Cervical cancer ( 23817570) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 23000144 20639880) Ulcerative colitis ( 20228799) White blood cell count ( 21738480)
Protein-Protein Interactions		6 interactors: GSDMB IGF1 IGF2 INO80B KLK2 TF	7 interactors: AGT APP HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1
Entrez ID		3485	55876
HPRD ID		00898	17082
Ensembl ID		ENSG00000115457	ENSG00000073605
Uniprot IDs		C9JMY1 P18065	Q8TAX9
PDB IDs		2H7T
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Exocytosis Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Pancreas Development Secretion Regulation Of Glucose Metabolic Process Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Response To Wounding Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Myoblast Proliferation Myoblast Proliferation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Acute-phase Response Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Response To Abiotic Stimulus Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Acute Inflammatory Response Regulation Of ERBB Signaling Pathway Developmental Cell Growth Uterine Smooth Muscle Contraction Response To Methanol Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Secretion By Cell Feeding Behavior Regulation Of Multicellular Organism Growth Response To Estradiol Regulation Of Growth Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Response To Triglyceride Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Secretion Cell Activation Cell Growth Angiotensin-mediated Drinking Behavior Smooth Muscle Cell Proliferation Collateral Sprouting In Absence Of Injury Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Regulation Of Renal Output By Angiotensin Response To External Stimulus Response To Chromate Fibroblast Proliferation Astrocyte Activation
Tagcloud ?		anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain grasp harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Difference) ?		anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain grasp harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Intersection) ?