IGFBP2 and KLK2

Number of citations of the paper that reports this interaction (PMID 11358513)
11

Data Source:
HPRD (in vitro)

		IGFBP2	KLK2
Gene Name		insulin-like growth factor binding protein 2, 36kDa	kallikrein-related peptidase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Serine-type Endopeptidase Activity
	Biological Process	Regulation Of Cell Growth Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Glucocorticoid	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS			PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)
Protein-Protein Interactions		6 interactors: GSDMB IGF1 IGF2 INO80B KLK2 TF	14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		3485	3817
HPRD ID		00898	01006
Ensembl ID		ENSG00000115457	ENSG00000167751
Uniprot IDs		C9JMY1 P18065	B4DU77 P20151
PDB IDs		2H7T
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Exocytosis Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Pancreas Development Secretion Regulation Of Glucose Metabolic Process Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Response To Wounding Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Myoblast Proliferation Myoblast Proliferation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway
Tagcloud ?		anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?