IFNB1

Description		interferon beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of Immune System Process Regulation Of Transcription By RNA Polymerase II Response To Stress Defense Response Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Leukocyte Activation Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Type I Interferon-mediated Signaling Pathway Neuron Cellular Homeostasis Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of Lewy Body Formation Antiviral Innate Immune Response Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Beta-D-Glucose
Diseases
GWAS		Axial length ( 24144296)
Interacting Genes		8 interacting genes: IFNAR1 IFNAR2 PEX19 S100A1 S100A4 S100A6 S100B S100P
Entrez ID		3456
HPRD ID		00972
Ensembl ID		ENSG00000171855
Uniprot IDs		P01574
PDB IDs		1AU1
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Calcium Ion Binding RAGE Receptor Binding Response To Interferon-alpha Transition Metal Ion Binding Cellular Response To Interferon-beta Extracellular Region Response To Interferon-beta Cytokine Binding Protein Homodimerization Activity Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Identical Protein Binding Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT ATPase Binding Interferon Receptor Activity Positive Regulation Of Protein Localization To Nucleus Peroxisome Membrane Targeting Sequence Binding Ruffle Peroxisome Membrane Biogenesis Regulation Of Protein Localization To Nucleus Axonogenesis Protein Import Into Peroxisome Membrane Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Membrane Biogenesis Perinuclear Region Of Cytoplasm Negative Regulation Of Skeletal Muscle Cell Differentiation Receptor Complex Cellular Response To Interferon-alpha Protein Targeting To Peroxisome Protein Carrier Chaperone Positive Regulation Of Canonical NF-kappaB Signal Transduction Peroxisome Fission Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Respiration Tropomyosin Binding Neuron Projection Morphogenesis A Band Cell Projection Morphogenesis
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