IFNB1 and S100A1

Number of citations of the paper that reports this interaction (PubMedID 33322098)
72

Data Source:
BioGRID (pull down)

		IFNB1	S100A1
Description		interferon beta 1	S100 calcium binding protein A1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Sarcoplasmic Reticulum Z Disc M Band A Band I Band Protein-containing Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of Immune System Process Regulation Of Transcription By RNA Polymerase II Response To Stress Defense Response Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Leukocyte Activation Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Type I Interferon-mediated Signaling Pathway Neuron Cellular Homeostasis Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of Lewy Body Formation Antiviral Innate Immune Response Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Vasodilation Positive Regulation Of Sprouting Angiogenesis
Pathways		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs		Beta-D-Glucose	Olopatadine
Diseases
GWAS		Axial length ( 24144296)
Interacting Genes		8 interacting genes: IFNAR1 IFNAR2 PEX19 S100A1 S100A4 S100A6 S100B S100P	36 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 CLCF1 CNTF CTF1 DES FKBP4 GFAP GJA1 IFNB1 IL11 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1 TP53
Entrez ID		3456	6271
HPRD ID		00972	01489
Ensembl ID		ENSG00000171855	ENSG00000160678
Uniprot IDs		P01574	A0A0S2Z4H2 P23297
PDB IDs		1AU1	2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Calcium Ion Binding RAGE Receptor Binding Response To Interferon-alpha Transition Metal Ion Binding Cellular Response To Interferon-beta Extracellular Region Response To Interferon-beta Cytokine Binding Protein Homodimerization Activity Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Identical Protein Binding Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT ATPase Binding Interferon Receptor Activity Positive Regulation Of Protein Localization To Nucleus Peroxisome Membrane Targeting Sequence Binding Ruffle Peroxisome Membrane Biogenesis Regulation Of Protein Localization To Nucleus Axonogenesis Protein Import Into Peroxisome Membrane Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Membrane Biogenesis Perinuclear Region Of Cytoplasm Negative Regulation Of Skeletal Muscle Cell Differentiation Receptor Complex Cellular Response To Interferon-alpha Protein Targeting To Peroxisome Protein Carrier Chaperone Positive Regulation Of Canonical NF-kappaB Signal Transduction Peroxisome Fission Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Respiration Tropomyosin Binding Neuron Projection Morphogenesis A Band Cell Projection Morphogenesis	Calcium-dependent Protein Binding S100 Protein Binding Transition Metal Ion Binding Identical Protein Binding Calcium Ion Binding Calcium Ion-transporting ATPase Complex Negative Regulation Of Blood Circulation Regulation Of Blood Circulation Regulation Of System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Actinomycin D Cell Surface Receptor Signaling Pathway Via STAT Cell Body Response To Actinomycin D Cellular Response To UV-C Ciliary Neurotrophic Factor Receptor Binding Sarcoplasmic Reticulum Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Cell Membrane Potential Cytokine Activity Intercalated Disc Muscle System Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Antibiotic Negative Regulation Of ATP-dependent Activity RAGE Receptor Binding Developmental Process Relaxation Of Cardiac Muscle Response To Hypoxia Cell Activation Response To UV-C Sarcoplasmic Reticulum Response To Decreased Oxygen Levels Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Modulation Of Chemical Synaptic Transmission Regulation Of Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Oxygen Levels Astrocyte Activation Astrocyte Development Intracellular Calcium Ion Homeostasis Regulation Of Programmed Cell Death Regulation Of Heart Contraction Relaxation Of Muscle Cellular Response To UV Negative Regulation Of Heart Contraction Circadian Behavior Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Rhythmic Behavior
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