IFNB1 and IFNAR1

Number of citations of the paper that reports this interaction (PMID 1834641)
6

Data Source:
HPRD (in vivo)

		IFNB1	IFNAR1
Gene Name		interferon, beta 1, fibroblast	interferon (alpha, beta and omega) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Blood Coagulation Response To Virus Cytokine-mediated Signaling Pathway Natural Killer Cell Activation B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Interferon-beta B Cell Proliferation Defense Response To Bacterium Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Regulation of IFNA signaling Cellular Senescence Interferon Signaling Cytokine Signaling in Immune system Factors involved in megakaryocyte development and platelet production TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Oxidative Stress Induced Senescence TRAF6 mediated IRF7 activation Interferon alpha/beta signaling Innate Immune System	Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs		Beta-D-Glucose Alpha-D-Mannose	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		2 interactors: IFNAR1 IFNAR2	21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70
Entrez ID		3456	3454
HPRD ID		00972	00126
Ensembl ID		ENSG00000171855	ENSG00000142166
Uniprot IDs		P01574 Q5VWC9	B4DNT3 P17181
PDB IDs		1AU1	3S98 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Type I Interferon Biosynthetic Process Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Type I Interferon Production Response To Interferon-alpha Regulation Of Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Cytokine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Cytokine Metabolic Process Positive Regulation Of Interleukin-1 Production Immune Response Regulation Of Immune System Process Defense Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interferon-gamma Production Response To External Stimulus Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Response To Organic Substance Cytokine Production Defense Response To Virus Regulation Of Signal Transduction Positive Regulation Of Protein Secretion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Stress T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion	Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus
Tagcloud ?		acting activates adaptor cgamp constitutively cytosol dimerization downstream effectively failed hsv ifns innate irf3 lethality mediates mediating messenger mita neurotropic screen sensing sensor sting tbk1 titers triggered viruses zdhhc1	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?		acting activates adaptor cgamp constitutively cytosol dimerization downstream effectively failed hsv ifns innate lethality mediates mediating messenger mita neurotropic screen sensing sensor sting tbk1 titers triggered viruses zdhhc1	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Intersection) ?		irf3