IFNB1 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 1834641)
0

Data Source:
HPRD (in vivo)

		IFNB1	IFNAR1
Description		interferon beta 1	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of Immune System Process Regulation Of Transcription By RNA Polymerase II Response To Stress Defense Response Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Leukocyte Activation Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Type I Interferon-mediated Signaling Pathway Neuron Cellular Homeostasis Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of Lewy Body Formation Antiviral Innate Immune Response Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration
Pathways		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs		Beta-D-Glucose	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b
Diseases
GWAS		Axial length ( 24144296)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		8 interacting genes: IFNAR1 IFNAR2 PEX19 S100A1 S100A4 S100A6 S100B S100P	26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3456	3454
HPRD ID		00972	00126
Ensembl ID		ENSG00000171855	ENSG00000142166
Uniprot IDs		P01574	A0A8V8TQK8 A0A994J6F6 P17181
PDB IDs		1AU1	3S98 3SE3 3SE4 4PO6 8Y31
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Calcium Ion Binding RAGE Receptor Binding Response To Interferon-alpha Transition Metal Ion Binding Cellular Response To Interferon-beta Extracellular Region Response To Interferon-beta Cytokine Binding Protein Homodimerization Activity Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Identical Protein Binding Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT ATPase Binding Interferon Receptor Activity Positive Regulation Of Protein Localization To Nucleus Peroxisome Membrane Targeting Sequence Binding Ruffle Peroxisome Membrane Biogenesis Regulation Of Protein Localization To Nucleus Axonogenesis Protein Import Into Peroxisome Membrane Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Membrane Biogenesis Perinuclear Region Of Cytoplasm Negative Regulation Of Skeletal Muscle Cell Differentiation Receptor Complex Cellular Response To Interferon-alpha Protein Targeting To Peroxisome Protein Carrier Chaperone Positive Regulation Of Canonical NF-kappaB Signal Transduction Peroxisome Fission Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Respiration Tropomyosin Binding Neuron Projection Morphogenesis A Band Cell Projection Morphogenesis	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression
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