NHSL2 and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NHSL2	TP53BP2
Description		NHS like 2	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding
	Biological Process	Cell Differentiation	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Platelet count ( 32888494) Plateletcrit ( 32888494)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		25 interacting genes: ABI3 ARID4B ATXN1 BTRC CLIC1 CTTN DYNLT1 GORASP2 HSF2BP INCA1 MAPK9 MTUS2 MYO15B NCK1 NCK2 PIH1D2 PLK1 PPP1R13B SH3RF1 SORBS3 TFCP2 TP53BP2 TRAF2 YWHAG YWHAH	119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		340527	7159
HPRD ID		15001	11803
Ensembl ID		ENSG00000204131	ENSG00000143514
Uniprot IDs		A0A0J9YY72 Q5HYW2	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?		Cytoplasm Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Vesicle Membrane Signal Transduction Lamellipodium Organization Positive Regulation Of Translation In Response To Stress Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Regulation Of Biological Quality Positive Regulation Of Supramolecular Fiber Organization Substrate-dependent Cell Migration, Cell Extension Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Translational Initiation In Response To Stress Receptor Tyrosine Kinase Binding Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Programmed Cell Death Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cytoskeleton Organization Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of PERK-mediated Unfolded Protein Response TOR Signaling Insulin-like Growth Factor Receptor Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription By RNA Polymerase II Modification Of Postsynaptic Structure Modification Of Synaptic Structure Cytoskeletal Anchor Activity	Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression
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