ITGB2 and PRTN3

Number of citations of the paper that reports this interaction (PubMedID 12960243)
0

Data Source:
HPRD (in vivo)

		ITGB2	PRTN3
Description		integrin subunit beta 2	proteinase 3
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Matrix Azurophil Granule Lumen Plasma Membrane Raft Membrane Raft Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding
	Biological Process	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration	Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs			Elafin
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Heel bone mineral density ( 28869591) Lymphocyte count ( 32888494) Neonatal white matter microstructure ( 33009551)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		3689	5657
HPRD ID		02506	01512
Ensembl ID		ENSG00000160255	ENSG00000196415
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	P24158
PDB IDs		1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ 7P2D 7USL 7USM	1FUJ
Enriched GO Terms of Interacting Partners?		Integrin Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Integrin-mediated Signaling Pathway Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Plasma Membrane Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Protein Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Protein Phosphorylation Regulation Of Superoxide Metabolic Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Phosphorylation Immune Effector Process Signaling Receptor Binding Extracellular Exosome Enzyme Binding Response To Bacterium Immune Response-regulating Signaling Pathway Activation Of Immune Response Histone H3T6 Kinase Activity Focal Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Regulation Of Phagocytosis Positive Regulation Of Locomotion	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Production Inflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Establishment Of Protein Localization Defense Response Positive Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-6 Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cell Activation Positive Regulation Of Chemokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Humoral Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Chemokine Production Positive Regulation Of Protein Transport Positive Regulation Of Transport Regulation Of Protein Secretion Immune System Process Negative Regulation Of Apoptotic Process Protease Binding Negative Regulation Of MiRNA Transcription Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Renin Secretion Into Blood Stream Regulation Of Secretion By Cell Regulation Of Immune Response Response To Lipopolysaccharide Myeloid Leukocyte Activation Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Vasculature Development Response To Molecule Of Bacterial Origin Regulation Of Secretion Regulation Of Protein Metabolic Process
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