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ITGB2 and ITGAX
Number of citations of the paper that reports this interaction (PMID
7621072
)
20
Data Source:
HPRD
(in vivo)
ITGB2
ITGAX
Gene Name
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, alpha X (complement component 3 receptor 4 subunit)
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Vesicle
Integrin AlphaL-beta2 Complex
Receptor Complex
Membrane Raft
Extracellular Vesicular Exosome
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Molecular Function
Glycoprotein Binding
Protein Binding
Protein Kinase Binding
ICAM-3 Receptor Activity
Protein Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Receptor Activity
Protein Binding
Metal Ion Binding
Biological Process
Toll-like Receptor Signaling Pathway
Leukocyte Migration Involved In Inflammatory Response
Apoptotic Process
Inflammatory Response
Cell Adhesion
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Aging
Blood Coagulation
Regulation Of Cell Shape
Natural Killer Cell Activation
Extracellular Matrix Organization
Neutrophil Chemotaxis
Heterotypic Cell-cell Adhesion
Toll-like Receptor 4 Signaling Pathway
Endodermal Cell Differentiation
Receptor Clustering
Endothelial Cell Migration
Innate Immune Response
Cellular Extravasation
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Activated T Cell Proliferation
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Adhesion
Integrin-mediated Signaling Pathway
Blood Coagulation
Organ Morphogenesis
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Leukocyte Migration
Pathways
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Innate Immune System
ECM proteoglycans
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Drugs
Simvastatin
Diseases
GWAS
Systemic lupus erythematosus (
18204098
)
Protein-Protein Interactions
41 interactors:
CD14
CD226
CD82
COPS3
COPS5
CYTH1
CYTH2
DAB1
DOK1
ESM1
FCER2
FHL2
FUT4
GNB2L1
HP
ICAM1
ICAM2
ICAM3
ICAM4
ICAM5
ILK
ITGAD
ITGAM
ITGAX
KNG1
NOTCH2NL
NUMB
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRTN3
PTK2
PTK2B
RANBP9
RDX
SYK
TLN1
VNN2
4 interactors:
C3
FCER2
ITGB2
JAM3
Entrez ID
3689
3687
HPRD ID
02506
01051
Ensembl ID
ENSG00000160255
ENSG00000140678
Uniprot IDs
A8MYE6
P05107
H3BN02
P20702
Q8TES5
PDB IDs
1JX3
1L3Y
1YUK
2JF1
2P26
2P28
2V7D
3K6S
3K71
3K72
1N3Y
2LUV
3K6S
3K71
3K72
Enriched GO Terms of Interacting Partners
?
Blood Coagulation
Hemostasis
Platelet Activation
Cell Activation
Regulation Of Body Fluid Levels
Wound Healing
Response To Wounding
Cell Adhesion
Regulation Of Immune System Process
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Single Organismal Cell-cell Adhesion
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Regulation Of Catalytic Activity
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Regulation Of Signal Transduction
Defense Response
Signal Transduction
Regulation Of Cellular Component Organization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Glial Cell Apoptotic Process
Movement Of Cell Or Subcellular Component
Locomotion
Regulation Of Signaling
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Response To External Stimulus
Cell Surface Receptor Signaling Pathway
Signaling
Positive Regulation Of Immune Response
Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Immune System Process
Positive Regulation Of Phosphorylation
Leukocyte Activation
Cell Communication
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Modification Process
Activation Of Phospholipase C Activity
Leukocyte Migration Involved In Inflammatory Response
Positive Regulation Of Humoral Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immunoglobulin Mediated Immune Response
Inflammatory Response
Regulation Of Humoral Immune Response
Positive Regulation Of Immune Response
Positive Regulation Of Angiogenesis
Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Positive Regulation Of Adaptive Immune Response
Cell-matrix Adhesion
Positive Regulation Of Type IIa Hypersensitivity
Regulation Of Adaptive Immune Response
Cell-substrate Adhesion
Regulation Of Angiogenesis
Leukocyte Migration
Positive Regulation Of Activation Of Membrane Attack Complex
Immune Response
Defense Response
Adaptive Immune Response
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Hypersensitivity
Positive Regulation Of Apoptotic Cell Clearance
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Extracellular Matrix Organization
Extracellular Structure Organization
Myeloid Progenitor Cell Differentiation
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of Killing Of Cells Of Other Organism
Regulation Of Apoptotic Cell Clearance
Blood Coagulation
Hemostasis
Complement Activation, Alternative Pathway
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Component Organization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Neutrophil Homeostasis
Single Organismal Cell-cell Adhesion
Immune System Process
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Protein Processing
Regulation Of Triglyceride Biosynthetic Process
Signaling
Regulation Of Body Fluid Levels
Cell Communication
Wound Healing
Heterotypic Cell-cell Adhesion
Tagcloud
?
a2
caucasians
cd8a
concepts
controversial
encode
highlighted
hla
icam
il1b
il2
itgal
loadings
meta
mining
modifier
nonrandomly
pooled
ranked
retrieved
sell
selp
shared
silico
spite
synapses
text
top
truly
Tagcloud (Difference)
?
a2
caucasians
cd8a
concepts
controversial
encode
highlighted
hla
icam
il1b
il2
itgal
loadings
meta
mining
modifier
nonrandomly
pooled
ranked
retrieved
sell
selp
shared
silico
spite
synapses
text
top
truly
Tagcloud (Intersection)
?