ITGB2 and CD226

Number of citations of the paper that reports this interaction (PMID 10591186)
29

Data Source:
HPRD (in vivo)

		ITGB2	CD226
Gene Name		integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	CD226 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft
	Molecular Function	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity	Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs		Simvastatin
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697) Type 1 diabetes ( 17554260) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2	4 interactors: FYN ITGB2 PVR PVRL2
Entrez ID		3689	10666
HPRD ID		02506	09252
Ensembl ID		ENSG00000160255	ENSG00000150637
Uniprot IDs		A8MYE6 P05107	J3QR77 Q15762
PDB IDs		1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity	Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response Positive Regulation Of Immune Response To Tumor Cell Activated T Cell Proliferation Positive Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Locomotion Regulation Of Immune System Process Viral Entry Into Host Cell Entry Into Host Cell T Cell Proliferation Response To External Stimulus Single Organismal Cell-cell Adhesion Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Proliferation Interaction With Host Mononuclear Cell Proliferation Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Proliferation Coreceptor-mediated Virion Attachment To Host Cell Cell Migration Cell Motility Positive Regulation Of Adaptive Immune Response Regulation Of Cell Shape Sperm Mitochondrion Organization Viral Life Cycle Regulation Of Adaptive Immune Response Cell Junction Assembly Cell-cell Junction Organization Fusion Of Virus Membrane With Host Plasma Membrane Leukocyte Migration Response To Virus T Cell Aggregation T Cell Activation Lymphocyte Aggregation
Tagcloud ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly	1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr
Tagcloud (Difference) ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly	1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr
Tagcloud (Intersection) ?