ITGB2 and CD226

Number of citations of the paper that reports this interaction (PubMedID 10591186)
0

Data Source:
HPRD (in vivo)

		ITGB2	CD226
Description		integrin subunit beta 2	CD226 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Extracellular Vesicle	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Integrin Binding Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration	Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Type II Interferon Production Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency	Type I diabetes mellitus
GWAS		Heel bone mineral density ( 28869591) Lymphocyte count ( 32888494) Neonatal white matter microstructure ( 33009551)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic widespread musculoskeletal pain ( 33331911) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494 31194788 27863252 22139419 19820697) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 23603763) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 21829393 17554260 25751624) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	4 interacting genes: FYN ITGB2 NECTIN2 PVR
Entrez ID		3689	10666
HPRD ID		02506	09252
Ensembl ID		ENSG00000160255	ENSG00000150637
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	J3QR77 Q15762
PDB IDs		1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ 7P2D 7USL 7USM	6ISB 6O3O
Enriched GO Terms of Interacting Partners?		Integrin Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Integrin-mediated Signaling Pathway Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Plasma Membrane Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Protein Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Protein Phosphorylation Regulation Of Superoxide Metabolic Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Phosphorylation Immune Effector Process Signaling Receptor Binding Extracellular Exosome Enzyme Binding Response To Bacterium Immune Response-regulating Signaling Pathway Activation Of Immune Response Histone H3T6 Kinase Activity Focal Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Regulation Of Phagocytosis Positive Regulation Of Locomotion	Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Cell Adhesion Molecule Binding Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Protein Targeting To Membrane Negative Regulation Of Immune Response Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Negative Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Immunity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Regulation Of Immune Response Leukocyte Mediated Cytotoxicity Immune Effector Process Virus Receptor Activity Positive Regulation Of Immune System Process Focal Adhesion Response To Glycine Regulation Of Innate Immune Response Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Positive Regulation Of Defense Response Regulation Of T Cell Mediated Immunity Cell-cell Adhesion Negative Regulation Of Hydrogen Peroxide Biosynthetic Process ICAM-3 Receptor Activity
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