ITGB2 and ICAM5

Number of citations of the paper that reports this interaction (PubMedID 8995416)
0

Data Source:
HPRD (in vitro)

		ITGB2	ICAM5
Description		integrin subunit beta 2	intercellular adhesion molecule 5
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Extracellular Vesicle	Plasma Membrane Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Integrin Binding Protein Binding
	Biological Process	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration	Phagocytosis Cell Adhesion Regulation Of Synapse Assembly Cell-cell Adhesion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Heel bone mineral density ( 28869591) Lymphocyte count ( 32888494) Neonatal white matter microstructure ( 33009551)	Blood protein levels ( 30072576) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 27863252)
Interacting Genes		56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	5 interacting genes: ACTN1 ITGAL ITGB2 PSEN1 PSEN2
Entrez ID		3689	7087
HPRD ID		02506	03509
Ensembl ID		ENSG00000160255	ENSG00000105376
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	Q8N6I2 Q9UMF0
PDB IDs		1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ 7P2D 7USL 7USM	3BN3 4OI9 4OIA 4OIB
Enriched GO Terms of Interacting Partners?		Integrin Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Integrin-mediated Signaling Pathway Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Plasma Membrane Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Protein Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Protein Phosphorylation Regulation Of Superoxide Metabolic Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Phosphorylation Immune Effector Process Signaling Receptor Binding Extracellular Exosome Enzyme Binding Response To Bacterium Immune Response-regulating Signaling Pathway Activation Of Immune Response Histone H3T6 Kinase Activity Focal Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Regulation Of Phagocytosis Positive Regulation Of Locomotion	Integrin AlphaL-beta2 Complex ICAM-3 Receptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Cell-cell Adhesion Cellular Extravasation Amyloid Precursor Protein Catabolic Process Neural Retina Development Kinetochore Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Integrin Complex Cell Activation Membrane Protein Proteolysis Receptor Clustering Cell Adhesion Leukocyte Cell-cell Adhesion Synaptic Membrane T Cell Activation Involved In Immune Response Negative Regulation Of Core Promoter Binding Specific Granule Membrane Cell Adhesion Molecule Binding Phagocytosis Structural Constituent Of Postsynapse Memory T Cell Extravasation Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Notch Signaling Pathway Platelet Morphogenesis Leukocyte Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neutrophil Degranulation Myeloid Leukocyte Activation Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Presynaptic Membrane Synaptic Vesicle Integrin Binding Membrane Leukocyte Activation Involved In Immune Response Cell-substrate Adhesion Cell Surface
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