ITGB2 and ESM1

Number of citations of the paper that reports this interaction (PubMedID 11544294)
0

Data Source:
HPRD (in vivo)

		ITGB2	ESM1
Description		integrin subunit beta 2	endothelial cell specific molecule 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Extracellular Vesicle	Extracellular Region Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Hepatocyte Growth Factor Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration	Angiogenesis Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Heel bone mineral density ( 28869591) Lymphocyte count ( 32888494) Neonatal white matter microstructure ( 33009551)	Cocaine dependence ( 31212010) Familial squamous cell lung carcinoma ( 29924316) Sense of smell ( 26632684) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	16 interacting genes: ADAM12 ANKS1A AQP1 BANP CTNNB1 FAM124B FRS3 HDAC7 HOXA1 ITGB2 MEOX2 NRF1 NUFIP2 PRKAB2 VGLL3 YY1
Entrez ID		3689	11082
HPRD ID		02506	03310
Ensembl ID		ENSG00000160255	ENSG00000164283
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	Q9NQ30
PDB IDs		1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ 7P2D 7USL 7USM
Enriched GO Terms of Interacting Partners?		Integrin Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Integrin-mediated Signaling Pathway Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Plasma Membrane Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Protein Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Protein Phosphorylation Regulation Of Superoxide Metabolic Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Phosphorylation Immune Effector Process Signaling Receptor Binding Extracellular Exosome Enzyme Binding Response To Bacterium Immune Response-regulating Signaling Pathway Activation Of Immune Response Histone H3T6 Kinase Activity Focal Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Regulation Of Phagocytosis Positive Regulation Of Locomotion	Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Vasculature Development Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Glomerulus Vasculature Development Regulation Of Angiogenesis Eye Morphogenesis Epithelium Development Camera-type Eye Morphogenesis Nitric Oxide Transmembrane Transporter Activity Vasculature Development Metanephric Proximal Convoluted Tubule Segment 2 Development Ephrin Receptor Binding Glycerol Transmembrane Transporter Activity Corticotropin Secretion Mesenchymal Stem Cell Differentiation Nucleoplasm Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Embryonic Pattern Specification Vasculogenesis SMAD Binding Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Protein Kinase Binding Renal Outer Medulla Development Renal Vesicle Formation Fibroblast Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development DNA-binding Transcription Factor Binding Limb Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of Cell Migration Involved In Sprouting Angiogenesis Immunoglobulin Heavy Chain V-D-J Recombination Sensory Organ Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Saliva Secretion Nucleus
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