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ITGAD and ITGB2
Number of citations of the paper that reports this interaction (PMID
8777714
)
26
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
ITGAD
ITGB2
Gene Name
integrin, alpha D
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integrin Complex
Cell Surface
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Vesicle
Integrin AlphaL-beta2 Complex
Receptor Complex
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Metal Ion Binding
Glycoprotein Binding
Protein Binding
Protein Kinase Binding
ICAM-3 Receptor Activity
Protein Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Biological Process
Immune Response
Integrin-mediated Signaling Pathway
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Activated T Cell Proliferation
Toll-like Receptor Signaling Pathway
Leukocyte Migration Involved In Inflammatory Response
Apoptotic Process
Inflammatory Response
Cell Adhesion
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Aging
Blood Coagulation
Regulation Of Cell Shape
Natural Killer Cell Activation
Extracellular Matrix Organization
Neutrophil Chemotaxis
Heterotypic Cell-cell Adhesion
Toll-like Receptor 4 Signaling Pathway
Endodermal Cell Differentiation
Receptor Clustering
Endothelial Cell Migration
Innate Immune Response
Cellular Extravasation
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Activated T Cell Proliferation
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Integrin cell surface interactions
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Innate Immune System
Drugs
Simvastatin
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
ICAM3
ITGB2
SHARPIN
VCAM1
41 interactors:
CD14
CD226
CD82
COPS3
COPS5
CYTH1
CYTH2
DAB1
DOK1
ESM1
FCER2
FHL2
FUT4
GNB2L1
HP
ICAM1
ICAM2
ICAM3
ICAM4
ICAM5
ILK
ITGAD
ITGAM
ITGAX
KNG1
NOTCH2NL
NUMB
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRTN3
PTK2
PTK2B
RANBP9
RDX
SYK
TLN1
VNN2
Entrez ID
3681
3689
HPRD ID
11785
02506
Ensembl ID
ENSG00000156886
ENSG00000160255
Uniprot IDs
Q13349
Q59H14
A8MYE6
P05107
PDB IDs
1JX3
1L3Y
1YUK
2JF1
2P26
2P28
2V7D
3K6S
3K71
3K72
Enriched GO Terms of Interacting Partners
?
Cellular Extravasation
Extracellular Matrix Organization
Extracellular Structure Organization
Single Organismal Cell-cell Adhesion
Regulation Of Immune Response
Cell Chemotaxis
Cell-matrix Adhesion
Cell-substrate Adhesion
Regulation Of CD40 Signaling Pathway
Protein Linear Polyubiquitination
Cell Adhesion
Leukocyte Migration
Regulation Of Immune System Process
Membrane To Membrane Docking
Leukocyte Cell-cell Adhesion
Aging
Chorio-allantoic Fusion
Lymphocyte Activation
Inflammatory Response
Leukocyte Migration Involved In Inflammatory Response
Chronic Inflammatory Response
Leukocyte Tethering Or Rolling
Leukocyte Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Chemotaxis
Heterotypic Cell-cell Adhesion
Labyrinthine Layer Morphogenesis
Activated T Cell Proliferation
Embryonic Morphogenesis
Cell Activation
Embryonic Placenta Morphogenesis
Apoptotic Nuclear Changes
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Endodermal Cell Differentiation
Response To Nicotine
Innate Immune Response
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Cell Migration
Keratinization
Neutrophil Chemotaxis
Neutrophil Migration
Response To Zinc Ion
Cell Motility
Positive Regulation Of Immune System Process
Receptor Clustering
Granulocyte Chemotaxis
Regulation Of Nitric Oxide Biosynthetic Process
Endoderm Formation
Blood Coagulation
Hemostasis
Platelet Activation
Cell Activation
Regulation Of Body Fluid Levels
Wound Healing
Response To Wounding
Cell Adhesion
Regulation Of Immune System Process
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Single Organismal Cell-cell Adhesion
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Regulation Of Catalytic Activity
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Regulation Of Signal Transduction
Defense Response
Signal Transduction
Regulation Of Cellular Component Organization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Glial Cell Apoptotic Process
Movement Of Cell Or Subcellular Component
Locomotion
Regulation Of Signaling
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Response To External Stimulus
Cell Surface Receptor Signaling Pathway
Signaling
Positive Regulation Of Immune Response
Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Immune System Process
Positive Regulation Of Phosphorylation
Leukocyte Activation
Cell Communication
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Modification Process
Activation Of Phospholipase C Activity
Tagcloud
?
a2
caucasians
cd8a
concepts
controversial
encode
highlighted
hla
icam
il1b
il2
itgal
loadings
meta
mining
modifier
nonrandomly
pooled
ranked
retrieved
sell
selp
shared
silico
spite
synapses
text
top
truly
Tagcloud (Difference)
?
a2
caucasians
cd8a
concepts
controversial
encode
highlighted
hla
icam
il1b
il2
itgal
loadings
meta
mining
modifier
nonrandomly
pooled
ranked
retrieved
sell
selp
shared
silico
spite
synapses
text
top
truly
Tagcloud (Intersection)
?