ABCA2 and CACNA1A

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		ABCA2	CACNA1A
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 2	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Endosome Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle ATP-binding Cassette (ABC) Transporter Complex	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body
	Molecular Function	Nucleotide Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Transport Regulation Of Intracellular Cholesterol Transport Response To Drug Cholesterol Homeostasis Response To Steroid Hormone Transmembrane Transport	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		ABC-family proteins mediated transport ABCA transporters in lipid homeostasis	Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CACNA1A CDK5RAP2	92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		20	773
HPRD ID		08967	03004
Ensembl ID		ENSG00000107331	ENSG00000141837
Uniprot IDs		Q9BZC7	B5TYJ1 O00555 Q9NS89
PDB IDs			3BXK
Enriched GO Terms of Interacting Partners?		Cerebellar Molecular Layer Development Vestibular Nucleus Development Musculoskeletal Movement, Spinal Reflex Action Cerebellum Maturation Negative Regulation Of Centriole Replication Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Centriole Replication Negative Regulation Of Hormone Biosynthetic Process Regulation Of Neurogenesis Pons Development Brain Development Negative Regulation Of Centrosome Duplication Head Development Cerebellar Purkinje Cell Differentiation Regulation Of Cell Development Cerebellar Purkinje Cell Layer Morphogenesis Central Nervous System Development Reflex Behavioral Response To Pain Regulation Of Spindle Checkpoint Neuromuscular Synaptic Transmission Regulation Of Hormone Biosynthetic Process Cerebellar Cortex Formation Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Calcium Ion Import Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Regulation Of Cell Cycle Checkpoint Establishment Of Mitotic Spindle Orientation Response To Pain Regulation Of Centrosome Duplication Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cerebellar Cortex Morphogenesis Synaptic Transmission, Glutamatergic Sulfur Amino Acid Metabolic Process Musculoskeletal Movement Calcium Ion-dependent Exocytosis Anion Homeostasis Spinal Cord Motor Neuron Differentiation	Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		abca3 abcb4 abcc1 abcc3 abcc5 abcg1 abcg2 acquiring acquring ahr cassette cisplatin crt dioxin jurkat kaempferol ls180 mvp origins senstivie slc29a1 slc29a2 snu601 tcdd tetrachlorodibenzo transporter transporters vault viabilities	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Difference) ?		abca3 abcb4 abcc1 abcc3 abcc5 abcg1 abcg2 acquiring acquring ahr cassette cisplatin crt dioxin jurkat kaempferol ls180 mvp origins senstivie slc29a1 slc29a2 snu601 tcdd tetrachlorodibenzo transporter transporters vault viabilities	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Intersection) ?