ABCA2 and CDK5RAP2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		ABCA2	CDK5RAP2
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 2	CDK5 regulatory subunit associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Endosome Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle ATP-binding Cassette (ABC) Transporter Complex	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cell Junction Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Transport Regulation Of Intracellular Cholesterol Transport Response To Drug Cholesterol Homeostasis Response To Steroid Hormone Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Chromosome Segregation Brain Development Neurogenesis Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Centrosome Organization Regulation Of Spindle Checkpoint
Pathways		ABC-family proteins mediated transport ABCA transporters in lipid homeostasis	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Response to statin therapy ( 20339536)
Protein-Protein Interactions		2 interactors: CACNA1A CDK5RAP2	24 interactors: ABCA2 C14orf1 CDK5 CDK5R1 CRMP1 EEF1G FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		20	55755
HPRD ID		08967	09740
Ensembl ID		ENSG00000107331	ENSG00000136861
Uniprot IDs		Q9BZC7	B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebellar Molecular Layer Development Vestibular Nucleus Development Musculoskeletal Movement, Spinal Reflex Action Cerebellum Maturation Negative Regulation Of Centriole Replication Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Centriole Replication Negative Regulation Of Hormone Biosynthetic Process Regulation Of Neurogenesis Pons Development Brain Development Negative Regulation Of Centrosome Duplication Head Development Cerebellar Purkinje Cell Differentiation Regulation Of Cell Development Cerebellar Purkinje Cell Layer Morphogenesis Central Nervous System Development Reflex Behavioral Response To Pain Regulation Of Spindle Checkpoint Neuromuscular Synaptic Transmission Regulation Of Hormone Biosynthetic Process Cerebellar Cortex Formation Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Calcium Ion Import Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Regulation Of Cell Cycle Checkpoint Establishment Of Mitotic Spindle Orientation Response To Pain Regulation Of Centrosome Duplication Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cerebellar Cortex Morphogenesis Synaptic Transmission, Glutamatergic Sulfur Amino Acid Metabolic Process Musculoskeletal Movement Calcium Ion-dependent Exocytosis Anion Homeostasis Spinal Cord Motor Neuron Differentiation	Serine Phosphorylation Of STAT3 Protein Regulation Of Protein Binding Serine Phosphorylation Of STAT Protein Regulation Of Microtubule-based Process Retrograde Axon Cargo Transport Regulation Of Intracellular Transport Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Process Regulation Of Binding Limbic System Development Regulation Of Neuron Death Regulation Of Organelle Organization Axon Development Cerebellum Development Microtubule-based Movement Cellular Component Assembly Metencephalon Development Negative Regulation Of Axon Extension Movement Of Cell Or Subcellular Component Anterograde Axon Cargo Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Hindbrain Development Microtubule-based Process Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Nervous System Development Neuron Projection Development Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Morphogenesis Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Death Cell Projection Morphogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Pre-mRNA Catabolic Process DNA Endoreduplication Regulation Of Cell Projection Organization Cell Part Morphogenesis Axon Cargo Transport Regulation Of Cytoskeleton Organization Response To Organic Cyclic Compound Positive Regulation Of Intracellular Transport Regulation Of Cell Cycle Organelle Organization
Tagcloud ?		abca3 abcb4 abcc1 abcc3 abcc5 abcg1 abcg2 acquiring acquring ahr cassette cisplatin crt dioxin jurkat kaempferol ls180 mvp origins senstivie slc29a1 slc29a2 snu601 tcdd tetrachlorodibenzo transporter transporters vault viabilities	acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?		abca3 abcb4 abcc1 abcc3 abcc5 abcg1 abcg2 acquiring acquring ahr cassette cisplatin crt dioxin jurkat kaempferol ls180 mvp origins senstivie slc29a1 slc29a2 snu601 tcdd tetrachlorodibenzo transporter transporters vault viabilities	acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?