ABCA2 and RSPH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ABCA2	RSPH1
Description		ATP binding cassette subfamily A member 2	radial spoke head component 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle ATP-binding Cassette (ABC) Transporter Complex Intracellular Membrane-bounded Organelle	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	Nucleotide Binding Lipid Transporter Activity ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Endopeptidase Regulator Activity Ceramide Floppase Activity Floppase Activity ABC-type Transporter Activity	Protein Binding
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Locomotory Behavior Response To Xenobiotic Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Steroid Metabolic Process Central Nervous System Myelin Formation Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Sphingosine Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Protein Metabolic Process Transmembrane Transport Regulation Of Protein Glycosylation Response To Cholesterol Negative Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Cholesterol Efflux Ceramide Translocation Transport Across Blood-brain Barrier Regulation Of Post-translational Protein Modification Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein Localization To Cell Surface	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle
Pathways		ABC transporters in lipid homeostasis
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Cutaneous mastocytosis ( 32752121) Cutaneous mastocytosis (adult) ( 32752121) Cutaneous mastocytosis (childhood) ( 32752121) Mastocytosis ( 32752121) Systemic mastocytosis ( 32752121) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: CACNA1A CDK5RAP2 DRD2 DYRK1A HTR6 LCOR RSPH1 RUNX1	125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793
Entrez ID		20	89765
HPRD ID		08967	11651
Ensembl ID		ENSG00000107331	ENSG00000160188
Uniprot IDs		Q9BZC7	Q8WYR4
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Transcription Corepressor Binding Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Microtubule Polymerization Tubulin Binding Histone H3T45 Kinase Activity Signaling Cell Communication Cell-cell Signaling Calcium Ion Transmembrane Import Into Cytosol Cardiac Muscle Tissue Regeneration Core-binding Factor Complex Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Sperm Flagellum Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendrite G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Response To Estradiol Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Cilium Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Microtubule Bundle Formation	Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?