ABCA2

Description		ATP binding cassette subfamily A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Microtubule Organizing Center Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle ATP-binding Cassette (ABC) Transporter Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Lipid Transporter Activity ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Endopeptidase Regulator Activity Ceramide Floppase Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Locomotory Behavior Response To Xenobiotic Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Steroid Metabolic Process Central Nervous System Myelin Formation Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Sphingosine Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Protein Metabolic Process Transmembrane Transport Regulation Of Protein Glycosylation Response To Cholesterol Negative Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Cholesterol Efflux Ceramide Translocation Transport Across Blood-brain Barrier Regulation Of Post-translational Protein Modification Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein Localization To Cell Surface
Pathways		ABC transporters in lipid homeostasis
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Cutaneous mastocytosis ( 32752121) Cutaneous mastocytosis (adult) ( 32752121) Cutaneous mastocytosis (childhood) ( 32752121) Mastocytosis ( 32752121) Systemic mastocytosis ( 32752121) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: CACNA1A CDK5RAP2 DRD2 DYRK1A HTR6 LCOR RSPH1 RUNX1
Entrez ID		20
HPRD ID		08967
Ensembl ID		ENSG00000107331
Uniprot IDs		Q9BZC7
PDB IDs
Enriched GO Terms of Interacting Partners?		Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Transcription Corepressor Binding Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Microtubule Polymerization Tubulin Binding Histone H3T45 Kinase Activity Signaling Cell Communication Cell-cell Signaling Calcium Ion Transmembrane Import Into Cytosol Cardiac Muscle Tissue Regeneration Core-binding Factor Complex Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Sperm Flagellum Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendrite G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Response To Estradiol Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Cilium Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Microtubule Bundle Formation
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