HTR2A and DACH1

Data Source: HiPPIP (Novel)

		HTR2A	DACH1
Name		5-hydroxytryptamine receptor 2A	dachshund family transcription factor 1
Structure
GO Annotations	Cellular Component	Neurofilament Plasma Membrane Caveola Membrane Axon Dendrite Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Shaft Synapse Postsynaptic Membrane Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Protein Tyrosine Kinase Activator Activity Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Temperature Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Glycolytic Process Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Positive Regulation Of Heat Generation Response To Cocaine Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Sensitization Behavioral Response To Cocaine Positive Regulation Of Inflammatory Response Sensory Perception Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Platelet Aggregation Positive Regulation Of DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process
Pathways		Serotonin receptors G alpha (q) signalling events	None
Drugs		Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Nandrolone decanoate Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil Volinanserin	None
GWAS		Cardiac hypertrophy ( 21348951 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Parkinson disease and lewy body pathology ( 25663231 ) Serum 25-Hydroxyvitamin D levels ( 29325163 ) Sjögren's syndrome ( 28076899 ) Subcutaneous adipose tissue ( 22589738 )	Adverse response to lamotrigine and phenytoin ( 22379998 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood urea nitrogen levels ( 29403010 31152163 ) Chronic kidney disease ( 20383146 ) Chronotype ( 30696823 ) Cleft palate ( 30452639 ) Creatinine levels ( 29403010 ) Diastolic blood pressure ( 30224653 29343252 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 29403010 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Longevity ( 20834067 ) Medication use (diuretics) ( 31015401 ) Metabolite levels ( 23823483 ) Mild obesity-related type 2 diabetes ( 34737425 ) Obsessive-compulsive disorder ( 22889921 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Restless legs syndrome ( 29029846 ) Serum uric acid levels ( 30993211 ) Spondylosis ( 33332786 ) Total cholesterol levels ( 30498476 ) Ulna and radius bone mineral density ( 30172743 ) Urate levels ( 23263486 31578528 ) Verbal declarative memory ( 25648963 ) White blood cell count ( 31217584 )
Novel Interactors		6 novel interactors: CTSG DACH1 DIRAS3 PCDH9 RFXAP SUGT1	2 novel interactors: HTR2A MYCBP2
Interacting Genes		19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I
Entrez ID		3356	1602
HPRD ID		01638	16031
Ensembl ID		ENSG00000102468	ENSG00000276644
Uniprot IDs		A0A7P0PKG8 P28223	Q9UI36
PDB IDs		6A93 6A94 6WGT 6WH4 6WHA 7RAN 7VOD 7VOE 7WC4 7WC5 7WC6 7WC7 7WC8 7WC9 8JT8 8UWL 8V6U 8ZMG	1L8R
GO Terms Enriched among Interactors		GDP Binding Postsynaptic Density Organization G Protein Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTPase Activity Postsynaptic Specialization Organization GTP Binding Nucleotide Binding Heterotrimeric G-protein Complex Maintenance Of Postsynaptic Density Structure Neuron Projection Organization Synapse Positive Regulation Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Platelet Activation Plasma Membrane Protein Localization To Synapse Maintenance Of Postsynaptic Specialization Structure Regulation Of Biological Quality Response To Lipid Synaptic Membrane Glutamatergic Synapse Positive Regulation Of Platelet Aggregation Acetylcholine Receptor Binding G Protein-coupled Receptor Binding Phototransduction, Visible Light Cytosol Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Protein Localization Protein Localization To Cell Junction Response To Ketone Hydrolase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cytoplasm G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Density Regulation Of Protein Secretion Detection Of Visible Light Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cellular Response To PH Response To Prostaglandin E Regulation Of Receptor-mediated Endocytosis Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cytoskeleton Organization	Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis