DACH1 and EYA3

Number of citations of the paper that reports this interaction (PubMedID 14628042)
0

Data Source:
HPRD (in vitro)

		DACH1	EYA3
Description		dachshund family transcription factor 1	EYA transcriptional coactivator and phosphatase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	DNA Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 29403010 31152163) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653 29343252) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Obsessive-compulsive disorder ( 22889921) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Spondylosis ( 33332786) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 23263486 31578528) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)	Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)
Interacting Genes		30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I	9 interacting genes: CRK DACH1 DSCAM DSCR9 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		1602	2140
HPRD ID		16031	09042
Ensembl ID		ENSG00000276644	ENSG00000158161
Uniprot IDs		Q9UI36	Q99504
PDB IDs		1L8R
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis	Transcription Regulator Complex Regulation Of Branching Involved In Ureteric Bud Morphogenesis Fungiform Papilla Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Regulation Of Kidney Development Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cranial Ganglion Development Regulation Of Morphogenesis Of A Branching Structure Tongue Development Regulation Of Morphogenesis Of An Epithelium Metanephric Mesenchyme Development Regulation Of Animal Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Tube Formation Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Population Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Skeletal System Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Ganglion Development Embryonic Organ Morphogenesis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Generation Of Neurons Middle Ear Morphogenesis Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Cell Differentiation Mesenchymal Cell Proliferation Muscle Cell Migration Protein Localization To Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Growth Positive Regulation Of Morphogenesis Of An Epithelium Protein Tyrosine Kinase Binding DNA-binding Transcription Factor Activity Thymus Development Developmental Process Anatomical Structure Morphogenesis Mesenchyme Development Regulation Of Synapse Organization Inner Ear Morphogenesis Regulation Of Transcription By RNA Polymerase II
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