DACH1 and RNF14

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DACH1	RNF14
Name		dachshund family transcription factor 1	ring finger protein 14
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair
Pathways		None	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood urea nitrogen levels ( 29403010 31152163 ) Chronic kidney disease ( 20383146 ) Chronotype ( 30696823 ) Cleft palate ( 30452639 ) Creatinine levels ( 29403010 ) Diastolic blood pressure ( 30224653 29343252 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 29403010 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Longevity ( 20834067 ) Medication use (diuretics) ( 31015401 ) Metabolite levels ( 23823483 ) Mild obesity-related type 2 diabetes ( 34737425 ) Obsessive-compulsive disorder ( 22889921 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Restless legs syndrome ( 29029846 ) Serum uric acid levels ( 30993211 ) Spondylosis ( 33332786 ) Total cholesterol levels ( 30498476 ) Ulna and radius bone mineral density ( 30172743 ) Urate levels ( 23263486 31578528 ) Verbal declarative memory ( 25648963 ) White blood cell count ( 31217584 )	Asthma ( 31959851 ) Superior temporal gyrus volume ( 31530798 )
Novel Interactors		2 novel interactors: HTR2A MYCBP2	1 novel interactors: FBN2
Interacting Genes		30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I	23 interacting genes: AR DACH1 ESR1 HNF1A HNRNPA1 NCOA4 NR3C1 PHF7 TAGLN TENT5A TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2U UBE2V1 UBE2W VDR
Entrez ID		1602	9604
HPRD ID		16031	05745
Ensembl ID		ENSG00000276644	ENSG00000013561
Uniprot IDs		Q9UI36	B7Z229 Q9UBS8
PDB IDs		1L8R	Not available
GO Terms Enriched among Interactors		Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transferase Activity Nuclear Receptor-mediated Signaling Pathway Estrogen Response Element Binding Protein Modification Process Intracellular Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Nuclear Steroid Receptor Activity Estrogen Receptor Signaling Pathway Nucleus Negative Regulation Of Osteoclast Proliferation Nucleoplasm Steroid Binding ATP Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mammary Gland Branching Involved In Pregnancy ISG15 Transferase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization ISG15-protein Conjugation Cellular Response To Lipid Cellular Response To Testosterone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Biomineral Tissue Development Nucleotide Binding Macromolecule Catabolic Process Positive Regulation Of Ossification Protein-containing Complex