HTR2A and ANKS1B

Number of citations of the paper that reports this interaction (PMID 16537434)
10

Data Source:
HPRD (two hybrid)

		HTR2A	ANKS1B
Gene Name		5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	ankyrin repeat and sterile alpha motif domain containing 1B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber	Cytoplasm Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Postsynaptic Membrane
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Ephrin Receptor Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 20966902) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 19721433) Waist circumference ( 20966902) Working memory ( 21107309)
Protein-Protein Interactions		16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	8 interactors: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 UBC
Entrez ID		3356	56899
HPRD ID		01638	07426
Ensembl ID		ENSG00000102468	ENSG00000185046
Uniprot IDs		P28223	B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8
PDB IDs			2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication	Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Transferase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorylation Regulation Of Catalytic Activity Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Proliferation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Diterpenoid Metabolic Process Regulation Of Phospholipase Activity Response To Light Stimulus Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Response To External Stimulus Cell Surface Receptor Signaling Pathway Central Nervous System Development Regulation Of Phospholipase A2 Activity
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Intersection) ?