HTR2A and ANKS1B

Number of citations of the paper that reports this interaction (PubMedID 16537434)
33

Data Source:
HPRD (two hybrid)

		HTR2A	ANKS1B
Description		5-hydroxytryptamine receptor 2A	ankyrin repeat and sterile alpha motif domain containing 1B
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GO Annotations	Cellular Component	Neurofilament Plasma Membrane Caveola Membrane Axon Dendrite Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Shaft Synapse Postsynaptic Membrane Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cajal Body Cell Projection Dendritic Spine Synapse
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Protein Tyrosine Kinase Activator Activity Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	Protein Binding Ephrin Receptor Binding
	Biological Process	Temperature Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Glycolytic Process Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Positive Regulation Of Heat Generation Response To Cocaine Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Sensitization Behavioral Response To Cocaine Positive Regulation Of Inflammatory Response Sensory Perception Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Platelet Aggregation Positive Regulation Of DNA Biosynthetic Process	Ephrin Receptor Signaling Pathway
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Nandrolone decanoate Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil Volinanserin
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Femur bone mineral density x serum urate levels interaction ( 34046847) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) Sjögren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)	Adult body size ( 32376654) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat percentage ( 31752434) Body mass index ( 20966902) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Body size at age 10 ( 32376654) Electrodermal activity ( 25387706) Hip circumference adjusted for BMI ( 34021172) Left-handedness ( 32989287) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Response to antipsychotic treatment ( 19721433) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Waist circumference ( 20966902)
Interacting Genes		19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	14 interacting genes: APP CASS4 CREBBP EGFR ERBB2 ERBB4 HSF2BP HTR2A LRP1 LRP2 NCK2 RHOA RIN1 UBC
Entrez ID		3356	56899
HPRD ID		01638	07426
Ensembl ID		ENSG00000102468	ENSG00000185046
Uniprot IDs		A0A7P0PKG8 P28223	A0A804HKX1 B1VKB5 B7Z9I9 F8VR14 Q6V0K8 Q7Z6G8
PDB IDs		6A93 6A94 6WGT 6WH4 6WHA 7RAN 7VOD 7VOE 7WC4 7WC5 7WC6 7WC7 7WC8 7WC9 8JT8 8UWL 8V6U 8ZMG	2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?		GDP Binding Postsynaptic Density Organization G Protein Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTPase Activity Postsynaptic Specialization Organization GTP Binding Nucleotide Binding Heterotrimeric G-protein Complex Maintenance Of Postsynaptic Density Structure Neuron Projection Organization Synapse Positive Regulation Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Platelet Activation Plasma Membrane Protein Localization To Synapse Maintenance Of Postsynaptic Specialization Structure Regulation Of Biological Quality Response To Lipid Synaptic Membrane Glutamatergic Synapse Positive Regulation Of Platelet Aggregation Acetylcholine Receptor Binding G Protein-coupled Receptor Binding Phototransduction, Visible Light Cytosol Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Protein Localization Protein Localization To Cell Junction Response To Ketone Hydrolase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cytoplasm G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Density Regulation Of Protein Secretion Detection Of Visible Light Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cellular Response To PH Response To Prostaglandin E Regulation Of Receptor-mediated Endocytosis Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cytoskeleton Organization	Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Metabolic Process Receptor Complex Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation ERBB2 Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Epidermal Growth Factor Receptor Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Signal Transduction Positive Regulation Of Metabolic Process Response To Growth Factor Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Astrocyte Activation Involved In Immune Response Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Phosphorylation ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Localization Basal Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade ERBB4 Signaling Pathway Endocytic Vesicle Clathrin-coated Pit
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