HTR2A and SUGT1

		HTR2A	SUGT1
Description		5-hydroxytryptamine receptor 2A	SGT1 assembly cochaperone of MIS12 kinetochore complex
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GO Annotations	Cellular Component	Neurofilament Plasma Membrane Caveola Membrane Axon Dendrite Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Shaft Synapse Postsynaptic Membrane Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Presynapse Glutamatergic Synapse	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Protein Tyrosine Kinase Activator Activity Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	Protein Binding Protein-folding Chaperone Binding LncRNA Binding
	Biological Process	Temperature Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Glycolytic Process Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Positive Regulation Of Heat Generation Response To Cocaine Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Sensitization Behavioral Response To Cocaine Positive Regulation Of Inflammatory Response Sensory Perception Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Platelet Aggregation Positive Regulation Of DNA Biosynthetic Process	Spindle Organization Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Kinetochore Assembly
Pathways		Serotonin receptors G alpha (q) signalling events	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Nandrolone decanoate Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil Volinanserin
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Femur bone mineral density x serum urate levels interaction ( 34046847) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) Sjögren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	18 interacting genes: BUB3 CEBPA CSNK2A1 DSN1 FNDC3B HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		3356	10910
HPRD ID		01638	09160
Ensembl ID		ENSG00000102468	ENSG00000165416
Uniprot IDs		A0A7P0PKG8 P28223	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs		6A93 6A94 6WGT 6WH4 6WHA 7RAN 7VOD 7VOE 7WC4 7WC5 7WC6 7WC7 7WC8 7WC9 8JT8 8UWL 8V6U 8ZMG	1RL1
Enriched GO Terms of Interacting Partners?		GDP Binding Postsynaptic Density Organization G Protein Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTPase Activity Postsynaptic Specialization Organization GTP Binding Nucleotide Binding Heterotrimeric G-protein Complex Maintenance Of Postsynaptic Density Structure Neuron Projection Organization Synapse Positive Regulation Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Platelet Activation Plasma Membrane Protein Localization To Synapse Maintenance Of Postsynaptic Specialization Structure Regulation Of Biological Quality Response To Lipid Synaptic Membrane Glutamatergic Synapse Positive Regulation Of Platelet Aggregation Acetylcholine Receptor Binding G Protein-coupled Receptor Binding Phototransduction, Visible Light Cytosol Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Protein Localization Protein Localization To Cell Junction Response To Ketone Hydrolase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cytoplasm G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Density Regulation Of Protein Secretion Detection Of Visible Light Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cellular Response To PH Response To Prostaglandin E Regulation Of Receptor-mediated Endocytosis Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cytoskeleton Organization	MIS12/MIND Type Complex Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation Chromosome, Centromeric Region Kinetochore Spindle Pole Protein Localization To Organelle Chromosome Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Nuclear Chromosome Segregation Nucleus Negative Regulation Of Cell Cycle Identical Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Calcium-dependent Protein Binding Endothelial Cell Migration S100 Protein Binding Regulation Of DNA Metabolic Process Nucleoplasm Protein Localization To Chromosome Positive Regulation Of Catabolic Process Chaperone-mediated Protein Complex Assembly Memory Protein Import Into Mitochondrial Matrix Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Hormone Regulation Of DNA Recombination Regulation Of Chromosome Segregation PcG Protein Complex Establishment Of Protein Localization To Organelle Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Cell Cycle Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Protein Localization To Mitochondrion Negative Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-dependent Protein Catabolic Process
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