DACH1 and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DACH1	AHCYL1
Description		dachshund family transcription factor 1	adenosylhomocysteinase like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Binding Adenosylhomocysteinase Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Monoatomic Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Monoatomic Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways			PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 29403010 31152163) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653 29343252) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Obsessive-compulsive disorder ( 22889921) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Spondylosis ( 33332786) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 23263486 31578528) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)	Height ( 31562340)
Interacting Genes		30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I	25 interacting genes: BID BTG3 CDKN2C CFTR DACH1 GEM HBQ1 HGS HSPA6 ITPR1 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165
Entrez ID		1602	10768
HPRD ID		16031	07613
Ensembl ID		ENSG00000276644	ENSG00000168710
Uniprot IDs		Q9UI36	A0A024R0A8 O43865
PDB IDs		1L8R	3MTG
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis
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