DACH1 and TEAD2

Number of citations: 55 (PubMedID 28205554)
Data Source: BioGRID (fluorescent resonance energy transfer)

		DACH1	TEAD2
Name		dachshund family transcription factor 1	TEA domain transcription factor 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol TEAD-YAP Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Notochord Development Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Mesenchyme Development Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		None	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood urea nitrogen levels ( 29403010 31152163 ) Chronic kidney disease ( 20383146 ) Chronotype ( 30696823 ) Cleft palate ( 30452639 ) Creatinine levels ( 29403010 ) Diastolic blood pressure ( 30224653 29343252 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 29403010 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Longevity ( 20834067 ) Medication use (diuretics) ( 31015401 ) Metabolite levels ( 23823483 ) Mild obesity-related type 2 diabetes ( 34737425 ) Obsessive-compulsive disorder ( 22889921 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Restless legs syndrome ( 29029846 ) Serum uric acid levels ( 30993211 ) Spondylosis ( 33332786 ) Total cholesterol levels ( 30498476 ) Ulna and radius bone mineral density ( 30172743 ) Urate levels ( 23263486 31578528 ) Verbal declarative memory ( 25648963 ) White blood cell count ( 31217584 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: HTR2A MYCBP2	None recorded
Interacting Genes		30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		1602	8463
HPRD ID		16031	03432
Ensembl ID		ENSG00000276644	ENSG00000074219
Uniprot IDs		Q9UI36	Q15562
PDB IDs		1L8R	3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH 7OYJ 7T2J 7T2K 7T2L 7T2M 7TYP 7TYQ 7TYU 8CUH 8E1O 8P29 8POJ 8POM 8PON 8PUX 8PUY 8RXL 8RXP 8RXQ 8RXV 8RYC 8YGQ
GO Terms Enriched among Interactors		Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Process Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Epithelial Cell Proliferation Protein Serine Kinase Activity Regulation Of Cell Differentiation Cell Population Proliferation Regulation Of Developmental Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Signaling Pathway Developmental Process Negative Regulation Of Metabolic Process