HTR2A and EIF3F

Number of citations of the paper that reports this interaction (PMID 16537434)
10

Data Source:
HPRD (two hybrid)

		HTR2A	EIF3F
Gene Name		5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	eukaryotic translation initiation factor 3, subunit F
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Proteolysis Gene Expression Protein Deubiquitination Cellular Protein Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)	Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	17 interactors: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MTOR PTN SHBG SMAD9 UBC
Entrez ID		3356	8665
HPRD ID		01638	04887
Ensembl ID		ENSG00000102468	ENSG00000175390
Uniprot IDs		P28223	B4DEW9 O00303
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication	Positive Regulation Of Cellular Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Learning Or Memory Positive Regulation Of Macromolecule Biosynthetic Process Cognition Positive Regulation Of Gene Expression Response To Abiotic Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Learning Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cell Growth Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Adult Behavior Regulation Of RNA Biosynthetic Process Single-organism Behavior Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Phosphorylation Behavior Response To Growth Factor Regulation Of Carbohydrate Utilization Primary Spermatocyte Growth Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Translation Visual Learning Visual Behavior Response To Organic Substance Response To Hypoxia
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Intersection) ?