DACH1 and SIN3A

Number of citations of the paper that reports this interaction (PubMedID 14525983)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DACH1	SIN3A
Description		dachshund family transcription factor 1	SIN3 transcription regulator family member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Transcription Repressor Complex Protein-containing Complex Sin3-type Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Intracellular Protein Localization Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebral Cortex Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Heterochromatin Formation Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Response To Methylglyoxal Type I Interferon-mediated Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine
Pathways			SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 29403010 31152163) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653 29343252) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Obsessive-compulsive disorder ( 22889921) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Spondylosis ( 33332786) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 23263486 31578528) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)	Caffeine consumption from tea ( 33287642) Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)
Interacting Genes		30 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC NAGK NCOR1 NF2 PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I	101 interacting genes: ARID4A ARID4B ATM BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CEBPA CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 DMRTC1B ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB1 PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 TSN ZBTB16
Entrez ID		1602	25942
HPRD ID		16031	09690
Ensembl ID		ENSG00000276644	ENSG00000169375
Uniprot IDs		Q9UI36	Q96ST3
PDB IDs		1L8R
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Chromatin Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Developmental Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death SMAD Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signaling Positive Regulation Of RNA Metabolic Process SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Heteromeric SMAD Protein Complex Regulation Of Protein Localization To Nucleus Transcription Cis-regulatory Region Binding Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Intracellular Glucose Homeostasis	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sin3-type Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Remodeling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process
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