DACH1 and FGF12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DACH1	FGF12
Gene Name		dachshund family transcription factor 1	fibroblast growth factor 12
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Involved In Preinitiation Complex Assembly RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Protein Binding	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity Ion Channel Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Respiratory Gaseous Exchange Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition	Regulation Of Membrane Depolarization Signal Transduction JNK Cascade Cell-cell Signaling Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity
Pathways
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Chronic kidney disease ( 20383146) Longevity ( 20834067) Obsessive-compulsive disorder ( 22889921) Urate levels ( 23263486)	Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Sleep quality ( 23728906)
Protein-Protein Interactions		18 interactors: AHCYL1 C1orf35 CREBBP EYA1 EYA3 FGF12 JUN NAGK NCOR1 PPIG RNF14 SIN3A SIX1 SMAD3 SMAD4 U2AF2 UBE2I ZCCHC10	13 interactors: APP COIL DACH1 DCTD IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L SRPK1 SRPK2 ZNF460
Entrez ID		1602	2257
HPRD ID		16031	03303
Ensembl ID		ENSG00000165659	ENSG00000114279
Uniprot IDs		Q9UI36	P61328
PDB IDs		1L8R	1Q1U
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heart Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heart Development Positive Regulation Of Transcription, DNA-templated Ureteric Bud Development Negative Regulation Of Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of Heart Morphogenesis Mesonephros Development Cellular Metabolic Process Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Macromolecule Biosynthetic Process Kidney Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of DNA-templated Transcription In Response To Stress SMAD Protein Signal Transduction Histone Dephosphorylation Response To Transforming Growth Factor Beta Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis	Negative Regulation Of Sodium Ion Transport RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Nucleobase-containing Compound Metabolic Process Regulation Of Transmembrane Transporter Activity Positive Regulation Of Viral Genome Replication Gene Expression Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suckling Behavior Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mating Behavior Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Cellular Macromolecular Complex Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Membrane Potential Regulation Of Metabolic Process Mating Neuromuscular Junction Development Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Regulation Of MRNA Splicing, Via Spliceosome Response To Stress Positive Regulation Of Neutrophil Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Nuclear Speck Organization Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Metabolic Process Negative Regulation Of Viral Process Response To Osmotic Stress Regulation Of MRNA Processing Regulation Of Synapse Structure Or Activity Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport MRNA Processing Feeding Behavior
Tagcloud ?		atlas basal bcl2 call chip conclusionthe considerations depend deregulation focused gata3 introductiongata3 luminal mammary methodsgata3 mutated proper regard representing resultswe seq shared shift signatures special subgroup suppressing thsd4 tumorigenesis	bisulfite breed broilers cgis chicken chickens contrasts cr1 differentially exons fgf14 fgf18 fgfr2 fgfr3 intergenic introns medip methylated poultry prominently recessive rock seq tails utrs validate wrr xh xinhua
Tagcloud (Difference) ?		atlas basal bcl2 call chip conclusionthe considerations depend deregulation focused gata3 introductiongata3 luminal mammary methodsgata3 mutated proper regard representing resultswe shared shift signatures special subgroup suppressing thsd4 tumorigenesis	bisulfite breed broilers cgis chicken chickens contrasts cr1 differentially exons fgf14 fgf18 fgfr2 fgfr3 intergenic introns medip methylated poultry prominently recessive rock tails utrs validate wrr xh xinhua
Tagcloud (Intersection) ?		seq