HTR2A and DLG4

Number of citations of the paper that reports this interaction (PMID 12682061)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		HTR2A	DLG4
Gene Name		5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	discs, large homolog 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		3356	1742
HPRD ID		01638	04199
Ensembl ID		ENSG00000102468	ENSG00000132535
Uniprot IDs		P28223	B7Z647 B9EGL1 P78352
PDB IDs			1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?