HTR2A and PON2

Number of citations of the paper that reports this interaction (PubMedID 16537434)
33

Data Source:
HPRD (two hybrid)

		HTR2A	PON2
Description		5-hydroxytryptamine receptor 2A	paraoxonase 2
Image			No pdb structure
GO Annotations	Cellular Component	Neurofilament Plasma Membrane Caveola Membrane Axon Dendrite Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Shaft Synapse Postsynaptic Membrane Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Presynapse Glutamatergic Synapse	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Protein Tyrosine Kinase Activator Activity Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity	Arylesterase Activity Protein Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Acyl-L-homoserine-lactone Lactonohydrolase Activity
	Biological Process	Temperature Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Glycolytic Process Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Positive Regulation Of Heat Generation Response To Cocaine Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Sensitization Behavioral Response To Cocaine Positive Regulation Of Inflammatory Response Sensory Perception Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Platelet Aggregation Positive Regulation Of DNA Biosynthetic Process	Response To Toxic Substance Lactone Catabolic Process
Pathways		Serotonin receptors G alpha (q) signalling events	Synthesis of 5-eicosatetraenoic acids
Drugs		Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Nandrolone decanoate Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil Volinanserin
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Femur bone mineral density x serum urate levels interaction ( 34046847) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) Sjögren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)	Apolipoprotein A1 levels ( 32203549) Yu-Zhi constitution type in type 2 diabetes ( 26169365)
Interacting Genes		19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	2 interacting genes: GRB2 HTR2A
Entrez ID		3356	5445
HPRD ID		01638	03903
Ensembl ID		ENSG00000102468	ENSG00000105854
Uniprot IDs		A0A7P0PKG8 P28223	A0A0J9YXF2 Q15165
PDB IDs		6A93 6A94 6WGT 6WH4 6WHA 7RAN 7VOD 7VOE 7WC4 7WC5 7WC6 7WC7 7WC8 7WC9 8JT8 8UWL 8V6U 8ZMG
Enriched GO Terms of Interacting Partners?		GDP Binding Postsynaptic Density Organization G Protein Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTPase Activity Postsynaptic Specialization Organization GTP Binding Nucleotide Binding Heterotrimeric G-protein Complex Maintenance Of Postsynaptic Density Structure Neuron Projection Organization Synapse Positive Regulation Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Platelet Activation Plasma Membrane Protein Localization To Synapse Maintenance Of Postsynaptic Specialization Structure Regulation Of Biological Quality Response To Lipid Synaptic Membrane Glutamatergic Synapse Positive Regulation Of Platelet Aggregation Acetylcholine Receptor Binding G Protein-coupled Receptor Binding Phototransduction, Visible Light Cytosol Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Protein Localization Protein Localization To Cell Junction Response To Ketone Hydrolase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cytoplasm G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Density Regulation Of Protein Secretion Detection Of Visible Light Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cellular Response To PH Response To Prostaglandin E Regulation Of Receptor-mediated Endocytosis Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Cytoskeleton Organization	Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Guanyl-nucleotide Exchange Factor Adaptor Activity Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Insulin Receptor Substrate Binding Grb2-EGFR Complex Regulation Of Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Serotonin Receptor Complex Artery Smooth Muscle Contraction 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Sensory Perception Of Temperature Stimulus Serotonin Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cell Body Fiber Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Urinary Bladder Smooth Muscle Contraction Nonassociative Learning Positive Regulation Of Platelet Aggregation Serotonin Receptor Signaling Pathway Tonic Smooth Muscle Contraction Positive Regulation Of Heat Generation Sensitization Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Positive Regulation Of Phospholipid Biosynthetic Process Neurofilament Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Tyrosine Kinase Activator Activity Vascular Associated Smooth Muscle Contraction Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Behavioral Response To Cocaine Regulation Of Cell Adhesion Schwann Cell Development Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Regulation Of Defense Response G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Glycolytic Process Regulation Of Dopamine Secretion Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
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