DNAJB1 and BRMS1

Number of citations of the paper that reports this interaction (PubMedID 16919237)
49

Data Source:
HPRD (in vivo)

		DNAJB1	BRMS1
Description		DnaJ heat shock protein family (Hsp40) member B1	BRMS1 transcriptional repressor and anoikis regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Transcription Regulator Inhibitor Activity	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Forebrain Development Cellular Response To Heat Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Protein Folding	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CEBPA CENPE CYP2C8 DNAJC3 DYRK3 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PPDPF PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36	50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1
Entrez ID		3337	25855
HPRD ID		05198	05879
Ensembl ID		ENSG00000132002	ENSG00000174744
Uniprot IDs		P25685 Q6FHS4	G5E9I4 Q9HCU9
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N 7NDX 8FE2 8FE5 8FEC	2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Intracellular Signal Transduction Response To Temperature Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Heat Cellular Response To Metal Ion Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Regulation Of Developmental Growth Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Intracellular Signaling Cassette Misfolded Protein Binding Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Apoptotic Process Heat Shock Protein Binding Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Response To Peptide Regulation Of Cell Growth Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Cellular Response To Topologically Incorrect Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Regulation Of Cell Development Signal Transduction Regulation Of Cell Cycle Response To Stress Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex
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