DNAJB1 and DNAJC3

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vitro)

		DNAJB1	DNAJC3
Description		DnaJ heat shock protein family (Hsp40) member B1	DnaJ heat shock protein family (Hsp40) member C3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Postsynapse Glutamatergic Synapse	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Transcription Regulator Inhibitor Activity	Protein Kinase Inhibitor Activity Protein Kinase Binding Protein-folding Chaperone Binding Misfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Forebrain Development Cellular Response To Heat Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Protein Folding	Regulation Of Translation Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Proteolysis Involved In Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation PKR-mediated signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Body mass index ( 28552196)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CEBPA CENPE CYP2C8 DNAJC3 DYRK3 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PPDPF PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36	8 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A OGT THAP12 TIRAP UBC
Entrez ID		3337	5611
HPRD ID		05198	03114
Ensembl ID		ENSG00000132002	ENSG00000102580
Uniprot IDs		P25685 Q6FHS4	A8KA82 Q13217
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N 7NDX 8FE2 8FE5 8FEC	2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Intracellular Signal Transduction Response To Temperature Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Heat Cellular Response To Metal Ion Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Regulation Of Developmental Growth Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Intracellular Signaling Cassette Misfolded Protein Binding Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Apoptotic Process Heat Shock Protein Binding Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Response To Peptide Regulation Of Cell Growth Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Cellular Response To Topologically Incorrect Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Regulation Of Cell Development Signal Transduction Regulation Of Cell Cycle Response To Stress Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein Regulation Of Translational Initiation Misfolded Protein Binding Regulation Of Protein-containing Complex Assembly Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Positive Regulation Of Cytokine Production Regulation Of Cellular Response To Stress Negative Regulation Of Translation Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Transcription Regulator Inhibitor Activity Cellular Response To Nutrient Levels Negative Regulation Of Translational Initiation Cellular Response To Heat Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Protein Folding Chaperone Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Chemokine Production Negative Regulation Of Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Translational Initiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Heat Regulation Of Interleukin-8 Production Negative Regulation Of Metabolic Process Negative Regulation Of Post-translational Protein Modification Regulation Of Response To Endoplasmic Reticulum Stress Denatured Protein Binding Regulation Of Translation Regulation Of Chemokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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