DNAJB1 and NQO1

Number of citations of the paper that reports this interaction (PubMedID 11821413)
0

Data Source:
HPRD (in vitro, in vivo)

		DNAJB1	NQO1
Description		DnaJ heat shock protein family (Hsp40) member B1	NAD(P)H quinone dehydrogenase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Transcription Regulator Inhibitor Activity	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Identical Protein Binding NADH Dehydrogenase (quinone) (non-electrogenic) Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Forebrain Development Cellular Response To Heat Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Protein Folding	Protein Polyubiquitination Ubiquinone Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Response To Toxic Substance Removal Of Superoxide Radicals Protein Catabolic Process Response To Lipopolysaccharide Cellular Response To Oxidative Stress Negative Regulation Of Protein Catabolic Process Vitamin E Metabolic Process Vitamin K Metabolic Process Innate Immune Response Cell Redox Homeostasis Response To Caloric Restriction Negative Regulation Of Ferroptosis
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	Regulation of ornithine decarboxylase (ODC) NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CEBPA CENPE CYP2C8 DNAJC3 DYRK3 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PPDPF PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36	10 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1
Entrez ID		3337	1728
HPRD ID		05198	00518
Ensembl ID		ENSG00000132002	ENSG00000181019
Uniprot IDs		P25685 Q6FHS4	B4DLR8 P15559
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N 7NDX 8FE2 8FE5 8FEC	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC 8C9J 8OK0 8PQN 8RFM 8RFN
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Intracellular Signal Transduction Response To Temperature Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Heat Cellular Response To Metal Ion Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Regulation Of Developmental Growth Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Intracellular Signaling Cassette Misfolded Protein Binding Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Apoptotic Process Heat Shock Protein Binding Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Response To Peptide Regulation Of Cell Growth Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Cellular Response To Topologically Incorrect Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Regulation Of Cell Development Signal Transduction Regulation Of Cell Cycle Response To Stress Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Post-translational Protein Modification Protein-folding Chaperone Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Binding Regulation Of Growth Histone Deacetylase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Cell Growth Enzyme Binding Hsp70 Protein Binding Regulation Of Mitophagy Protein-containing Complex Cellular Response To Heat Regulation Of Autophagy Of Mitochondrion Regulation Of Protein-containing Complex Assembly Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Heat Shock Protein Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Protein Stabilization Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Response To Heat
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