DNAJB1 and NQO1

Number of citations of the paper that reports this interaction (PMID 11821413)
9

Data Source:
HPRD (in vivo, in vitro)

		DNAJB1	NQO1
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 1	NAD(P)H dehydrogenase, quinone 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytosol Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Regulation Of Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Toxic Substance Removal Of Superoxide Radicals Response To Estradiol Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Response To Ethanol Oxidation-reduction Process
Pathways		HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Regulation of ornithine decarboxylase (ODC) Metabolism of amino acids and derivatives
Drugs			Menadione Dicumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione Cibacron Blue Flavin-Adenine Dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
Diseases
GWAS
Protein-Protein Interactions		28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36	5 interactors: DNAJB1 HSPA1A ING1 STUB1 TP53
Entrez ID		3337	1728
HPRD ID		05198	00518
Ensembl ID		ENSG00000132002	ENSG00000181019
Uniprot IDs		B4DX52 P25685 Q6FHS4	B4DLR8 P15559
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization	Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein Negative Regulation Of Cell Growth Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Protein Refolding Negative Regulation Of Growth Regulation Of Cellular Response To Heat Regulation Of Cell Growth Cellular Response To Heat Cellular Response To Stress Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus ER-nucleus Signaling Pathway Negative Regulation Of Cell Proliferation Response To Heat Protein Import Into Nucleus Nuclear Import Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromitophagy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Oligodendrocyte Apoptotic Process Protein Import Response To Endoplasmic Reticulum Stress Protein Localization To Nucleus Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organic Substance Negative Regulation Of Helicase Activity Response To Transforming Growth Factor Beta Response To Temperature Stimulus Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Nucleocytoplasmic Transport Nuclear Transport Ubiquitin-dependent SMAD Protein Catabolic Process Mitochondrial DNA Repair Protein Folding
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absorbance antioxidants assayed benzyl centrifugal edible fcpc fractionate hepa1c1c7 inducer isothiocyanate itc itcs leaves moringa nad nutritious oleifera orac oxidoreductase partition polyphenol polyphenols preparatory quinone rhamnosyloxy sf sulforaphane tropical
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absorbance antioxidants assayed benzyl centrifugal edible fcpc fractionate hepa1c1c7 inducer isothiocyanate itc itcs leaves moringa nad nutritious oleifera orac oxidoreductase partition polyphenol polyphenols preparatory quinone rhamnosyloxy sf sulforaphane tropical
Tagcloud (Intersection) ?