HSF2 and MECOM

Number of citations of the paper that reports this interaction (PubMedID 23858473)
53

Data Source:
BioGRID (two hybrid)

		HSF2	MECOM
Description		heat shock transcription factor 2	MDS1 and EVI1 complex locus
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Methylation Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation
Pathways			PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription Formation of the nephric duct
Drugs
Diseases			Chronic myeloid leukemia (CML)
GWAS		Atrial fibrillation ( 30061737 29892015 28416822) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte count ( 32888494 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 27841878 30224653) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)	Aging (time to event) ( 21782286) Appendicular lean mass ( 33097823) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27618452 27841878 32902719 21909115 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31959993 29617998 29785010) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200 25849990) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 27618452 27618447 21909115 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP HSPA4 MECOM MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I	63 interacting genes: ANKRD11 ARHGEF37 BAG6 BRD2 CAGE1 CAVIN1 CCDC180 CEP128 CHERP CLIC3 CREBBP CSNK2A1 CTBP1 CTBP2 DZIP1 EPB41L3 GAS7 GOLGA6L1 GTF3C2 HDAC1 HDAC4 HIC1 HSF2 HSF2BP JUN KAT2B KNSTRN LNX2 MAGI3 MBD3 NIBAN2 NMRAL1 OIP5 PACSIN2 PCBP2 PIK3R3 PKM PLXNB1 PPP1CA PPP1R9A PPP1R9B PRMT1 RB1CC1 RBM11 RNF31 SF3B1 SMAD1 SMAD2 SMAD3 SMAD4 SNX9 SOX13 SREBF1 TLE5 TPR TRIM11 TRIM26 TRIM58 TSNAX UBAC1 UBE2I VPS39 ZC4H2
Entrez ID		3298	2122
HPRD ID		00779	01310
Ensembl ID		ENSG00000025156	ENSG00000085276
Uniprot IDs		Q03933 Q9BS48	A0A0C3SFZ7 C7FEN9 Q03112
PDB IDs		5D8K 5D8L 5HDK 7DCI 7DCU	6BW3
Enriched GO Terms of Interacting Partners?		Cytoskeleton Regulation Of Cell Cycle Female Meiotic Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Organelle Organization Cytoplasm Centrosome Positive Regulation Of Chromosome Separation PML Body Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Nuclear Division Spindle Pole Positive Regulation Of Cell Cycle Protein Sumoylation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Separation Meiotic Nuclear Division Protein Modification By Small Protein Conjugation Cell Division Protein Tag Activity Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization SUMO Transferase Activity Regulation Of Sister Chromatid Segregation RNA Polymerase II Transcription Initiation Surveillance Post-translational Protein Modification Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Mitotic Nuclear Division Regulation Of Centriole Replication Nucleoplasm Ubiquitin-like Protein Ligase Binding Cytosol Positive Regulation Of Mitotic Cell Cycle Presynaptic Cytosol Postsynaptic Cytosol Mitotic Spindle Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Nuclear RNA Surveillance Cell Cycle Phase Transition Chromosome, Centromeric Region Kinetochore Chromosome RNA Surveillance	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Chromatin I-SMAD Binding DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Binding Chromatin Binding Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Developmental Process Negative Regulation Of Metabolic Process R-SMAD Binding Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Endoderm Development Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Co-SMAD Binding Peptidyl-lysine Acetylation Primary MiRNA Processing Homomeric SMAD Protein Complex Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Transcription Coregulator Binding
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