HSF2 and PCGF2

Number of citations of the paper that reports this interaction (PubMedID 18211895)
28

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		HSF2	PCGF2
Description		heat shock transcription factor 2	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015 28416822) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte count ( 32888494 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 27841878 30224653) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		20 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP HSPA4 MECOM MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I	26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		3298	7703
HPRD ID		00779	10621
Ensembl ID		ENSG00000025156	ENSG00000277258
Uniprot IDs		Q03933 Q9BS48	P35227
PDB IDs		5D8K 5D8L 5HDK 7DCI 7DCU
Enriched GO Terms of Interacting Partners?		Cytoskeleton Regulation Of Cell Cycle Female Meiotic Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Organelle Organization Cytoplasm Centrosome Positive Regulation Of Chromosome Separation PML Body Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Nuclear Division Spindle Pole Positive Regulation Of Cell Cycle Protein Sumoylation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Separation Meiotic Nuclear Division Protein Modification By Small Protein Conjugation Cell Division Protein Tag Activity Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization SUMO Transferase Activity Regulation Of Sister Chromatid Segregation RNA Polymerase II Transcription Initiation Surveillance Post-translational Protein Modification Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Mitotic Nuclear Division Regulation Of Centriole Replication Nucleoplasm Ubiquitin-like Protein Ligase Binding Cytosol Positive Regulation Of Mitotic Cell Cycle Presynaptic Cytosol Postsynaptic Cytosol Mitotic Spindle Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Nuclear RNA Surveillance Cell Cycle Phase Transition Chromosome, Centromeric Region Kinetochore Chromosome RNA Surveillance	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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