HSF2 and DERA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSF2	DERA
Description		heat shock transcription factor 2	deoxyribose-phosphate aldolase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Deoxyribose-phosphate Aldolase Activity Protein Binding Lyase Activity
	Biological Process	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II	Pentose-phosphate Shunt Deoxyribonucleotide Catabolic Process Carbohydrate Catabolic Process Deoxyribonucleoside Catabolic Process Deoxyribose Phosphate Catabolic Process
Pathways			Neutrophil degranulation Pentose phosphate pathway
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015 28416822) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte count ( 32888494 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 27841878 30224653) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Bone mineral density (hip) and age at menarche ( 26312577) Chronotype ( 30696823) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		20 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP HSPA4 MECOM MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I	1 interacting genes: HSF2
Entrez ID		3298	51071
HPRD ID		00779	13138
Ensembl ID		ENSG00000025156	ENSG00000023697
Uniprot IDs		Q03933 Q9BS48	E9PPM8 G3V158 Q9Y315
PDB IDs		5D8K 5D8L 5HDK 7DCI 7DCU
Enriched GO Terms of Interacting Partners?		Cytoskeleton Regulation Of Cell Cycle Female Meiotic Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Organelle Organization Cytoplasm Centrosome Positive Regulation Of Chromosome Separation PML Body Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Nuclear Division Spindle Pole Positive Regulation Of Cell Cycle Protein Sumoylation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Separation Meiotic Nuclear Division Protein Modification By Small Protein Conjugation Cell Division Protein Tag Activity Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization SUMO Transferase Activity Regulation Of Sister Chromatid Segregation RNA Polymerase II Transcription Initiation Surveillance Post-translational Protein Modification Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Mitotic Nuclear Division Regulation Of Centriole Replication Nucleoplasm Ubiquitin-like Protein Ligase Binding Cytosol Positive Regulation Of Mitotic Cell Cycle Presynaptic Cytosol Postsynaptic Cytosol Mitotic Spindle Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Nuclear RNA Surveillance Cell Cycle Phase Transition Chromosome, Centromeric Region Kinetochore Chromosome RNA Surveillance
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