HSF2 and CDC27

Number of citations of the paper that reports this interaction (PMID 20937767)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HSF2	CDC27
Gene Name		heat shock transcription factor 2	cell division cycle 27
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Homodimerization Activity	Protein Binding Protein Phosphatase Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Spermatogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter	Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CDC20 CDC27 CUL3 HSF1 HSF2BP MTUS2 NCAPG NUP62 PCGF2 PPP2R1A SUMO1 SUMO2 SUMO3 TPM3 UBE2I WDR5	30 interactors: ADNP ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CCNA2 CCNB1 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FBXO5 FZR1 GKN1 HOXC10 HSF2 MAD2L1 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBE2S
Entrez ID		3298	996
HPRD ID		00779	00304
Ensembl ID		ENSG00000025156	ENSG00000004897
Uniprot IDs		Q03933 Q9BS48	B4DL80 G5EA36 P30260
PDB IDs			3T1N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Catabolic Process Peptidyl-lysine Modification Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Organelle Organization Cellular Protein Modification Process Cell Cycle Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Metabolic Process Mitotic Nuclear Division Cell Cycle Process Regulation Of Proteolysis Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Cellular Protein Metabolic Process Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Positive Regulation Of Proteasomal Protein Catabolic Process Peptidyl-amino Acid Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Nucleus Organization Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Ubiquitination Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process	Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Ligase Activity Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Cell Cycle Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Catabolic Process
Tagcloud ?		abiotic ap2 brachiata characterisation chlorophyll dehydration dehydrins dreb electrolyte erd10b erd10d germination glutamic halophyte hsp18 hsp26 hyperionic hyperosmotic lea5 photosynthesis plc3 salicornia sbdreb2a tf tfs transgenics wildtype wue zfp	aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent
Tagcloud (Difference) ?		abiotic ap2 brachiata characterisation chlorophyll dehydration dehydrins dreb electrolyte erd10b erd10d germination glutamic halophyte hsp18 hsp26 hyperionic hyperosmotic lea5 photosynthesis plc3 salicornia sbdreb2a tf tfs transgenics wildtype wue zfp	aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent
Tagcloud (Intersection) ?