APCS and FCGR3B

Number of citations of the paper that reports this interaction (PubMedID 11359830)
0

Data Source:
HPRD (in vitro)

		APCS	FCGR3B
Description		amyloid P component, serum	Fc gamma receptor IIIb
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding	IgG Receptor Activity IgG Binding GPI Anchor Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process	Antibody-dependent Cellular Cytotoxicity Immune Response Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway
Pathways		Amyloid fiber formation	Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs		Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Muromonab Alemtuzumab Alefacept Natalizumab Palivizumab Daclizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576) C-reactive protein ( 22939635) Neonatal white matter microstructure ( 33009551)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Blood protein levels ( 30072576) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233 28067908) Limited cutaneous systemic scleroderma ( 29293537) Monocyte count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	2 interacting genes: APCS IGHG1
Entrez ID		325	2215
HPRD ID		00101	09951
Ensembl ID		ENSG00000132703	ENSG00000162747
Uniprot IDs		P02743 V9HWP0	A0A3B3ISU3 H0Y4U3 O75015
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?		IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent	Acute Inflammatory Response Blood Microparticle Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Negative Regulation Of Monocyte Differentiation Complement Component C1q Complex Binding Inflammatory Response Antibody-dependent Cellular Cytotoxicity IgG Immunoglobulin Complex Immunoglobulin Complex, Circulating Virion Binding Hypersensitivity Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Glycoprotein Metabolic Process Defense Response To Other Organism Host-mediated Suppression Of Viral Proces Defense Response To Symbiont Immunoglobulin Receptor Binding Acute Inflammatory Response To Antigenic Stimulus Regulation Of Monocyte Differentiation Immunoglobulin Complex Chaperone-mediated Protein Complex Assembly Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Antigen Binding Complement Activation, Classical Pathway Inflammatory Response To Antigenic Stimulus Acute-phase Response Immunoglobulin Mediated Immune Response Immune Response Defense Response Response To External Biotic Stimulus Negative Regulation Of Myeloid Leukocyte Differentiation Regulation Of Acute Inflammatory Response B Cell Receptor Signaling Pathway B Cell Mediated Immunity Complement Activation Extracellular Space Antibacterial Humoral Response Host-mediated Perturbation Of Viral Process Negative Regulation Of Wound Healing Negative Regulation Of Viral Process Regulation Of Immune System Process Leukocyte Mediated Cytotoxicity Negative Regulation Of Myeloid Cell Differentiation Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Host-mediated Perturbation Of Symbiont Process Unfolded Protein Binding
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