APCS and GK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		APCS	GK
Gene Name		amyloid P component, serum	glycerol kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle	Nucleus Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding	Glycerol Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Glycerol Metabolic Process Triglyceride Metabolic Process Phosphorylation Triglyceride Biosynthetic Process Glycerol Catabolic Process Glucose Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerol-3-phosphate Biosynthetic Process
Pathways		Amyloids	Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis
Drugs		Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Diseases
GWAS		C-reactive protein ( 22939635)
Protein-Protein Interactions		17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	11 interactors: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA
Entrez ID		325	2710
HPRD ID		00101	08363
Ensembl ID		ENSG00000132703	ENSG00000198814
Uniprot IDs		P02743	B4DH54 P32189
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway	Vitamin Metabolic Process Regulation Of Translational Initiation Glycerophosphate Shuttle Cellular Response To Organic Cyclic Compound Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Exo-alpha-sialidase Activity Steroid Hormone Mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Alkaloid Catabolic Process Hormone-mediated Signaling Pathway Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Hormone Stimulus Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Response To Xenobiotic Stimulus Vitamin B6 Metabolic Process Glycerol-3-phosphate Catabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Monoterpenoid Metabolic Process NADH Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Calcitriol Biosynthetic Process From Calciol Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Monocyte Differentiation Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Branching Involved In Prostate Gland Morphogenesis Alkaloid Metabolic Process Steroid Metabolic Process Glycerol-3-phosphate Metabolic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Positive Regulation Of Glycolytic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Translation Oxidative Demethylation Chaperone-mediated Protein Complex Assembly Vitamin D Metabolic Process Muscle Organ Development Response To Hormone Regulation Of Monocyte Differentiation Positive Regulation Of Translational Initiation Endothelial Cell Chemotaxis Negative Regulation Of Acute Inflammatory Response Cellular Lipid Metabolic Process
Tagcloud ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Difference) ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Intersection) ?